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TRAIL, Fas Ligand, TNF and TLR3 in c...

Micheau, Olivier.

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TRAIL, Fas Ligand, TNF and TLR3 in cancer

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	TRAIL, Fas Ligand, TNF and TLR3 in cancer/ edited by Olivier Micheau.
其他作者:	Micheau, Olivier.
出版者:	Cham :Springer International Publishing : : 2017.,
面頁冊數:	xiii, 317 p. :ill., digital ;24 cm.
內容註:	Resistance to TRAIL Pathway-Targeted Therapeutics in Cancer -- TRAIL-R3/R4 and Inhibition of TRAIL Signalling in Cancer -- IAPs and Resistance to Death Receptors in Cancer -- Bcl-2 Proteins and TRAIL Resistance in Melanoma -- Regulation of Caspase-Mediated Apoptosis by the Tumor Suppressor Par-4 -- Stem Cell Regulation by Death Ligands and Their Use in Cell Therapy -- Atypical Immune Functions of CD95/CD95L -- TLR3 is a Death Receptor Target in Cancer Therapy -- Fas/CD95, Lipid Rafts and Cancer -- Role of Sphingolipids in Death Receptor Signalling -- Post-Translational Modifications and Death Receptor Signalling -- System Modeling of Receptor-Induced Apoptosis.
Contained By:	Springer eBooks
標題:	Cancer - Treatment. -
電子資源:	http://dx.doi.org/10.1007/978-3-319-56805-8
ISBN:	9783319568058

TRAIL, Fas Ligand, TNF and TLR3 in cancer
TRAIL, Fas Ligand, TNF and TLR3 in cancer[electronic resource] /edited by Olivier Micheau. - Cham :Springer International Publishing :2017. - xiii, 317 p. :ill., digital ;24 cm. - Resistance to targeted anti-cancer therapeutics,v.122196-5501 ;. - Resistance to targeted anti-cancer therapeutics ;v.12..

Resistance to TRAIL Pathway-Targeted Therapeutics in Cancer -- TRAIL-R3/R4 and Inhibition of TRAIL Signalling in Cancer -- IAPs and Resistance to Death Receptors in Cancer -- Bcl-2 Proteins and TRAIL Resistance in Melanoma -- Regulation of Caspase-Mediated Apoptosis by the Tumor Suppressor Par-4 -- Stem Cell Regulation by Death Ligands and Their Use in Cell Therapy -- Atypical Immune Functions of CD95/CD95L -- TLR3 is a Death Receptor Target in Cancer Therapy -- Fas/CD95, Lipid Rafts and Cancer -- Role of Sphingolipids in Death Receptor Signalling -- Post-Translational Modifications and Death Receptor Signalling -- System Modeling of Receptor-Induced Apoptosis.

This volume provides the current understanding of death receptor's/TLR3 signaling regulation in cancer. Death receptors, including TRAIL-R1, TRAIL-R2, Fas and TNF-RI, owing to their ability to trigger apoptosis and to contribute to the elimination of cancer cells by the immune system have been considered, to variable extent, as important therapeutic targets for cancer therapy. But an increasing body of evidence suggests that some of these receptors may also contribute to tumorigenesis, or that new players such as TLR3 may be targeted for cancer therapy due to their ability to behave like death receptors.

ISBN: 9783319568058

Standard No.: 10.1007/978-3-319-56805-8doiSubjects--Topical Terms:

618125
Cancer
--Treatment.

LC Class. No.: RC270.8

Dewey Class. No.: 616.99406

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520 $a This volume provides the current understanding of death receptor's/TLR3 signaling regulation in cancer. Death receptors, including TRAIL-R1, TRAIL-R2, Fas and TNF-RI, owing to their ability to trigger apoptosis and to contribute to the elimination of cancer cells by the immune system have been considered, to variable extent, as important therapeutic targets for cancer therapy. But an increasing body of evidence suggests that some of these receptors may also contribute to tumorigenesis, or that new players such as TLR3 may be targeted for cancer therapy due to their ability to behave like death receptors.
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