東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Systems pharmacology and pharmacodyn...

Mager, Donald E.

FindBook

Google Book

Amazon

博客來

Systems pharmacology and pharmacodynamics

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Systems pharmacology and pharmacodynamics/ edited by Donald E. Mager, Holly H.C. Kimko.
其他作者:	Mager, Donald E.
出版者:	Cham :Springer International Publishing : : 2016.,
面頁冊數:	xiii, 511 p. :ill., digital ;24 cm.
內容註:	Role of Systems Modeling in Regulatory Drug Approval -- Quantitative Systems Pharmacology: Applications and Adoption in Drug Development -- Systems Pharmacology: An Overview -- Discrete dynamic modeling: a network approach for systems pharmacology -- Kinetic Models of Biochemical Signaling Networks -- Mechanistic Models of Physiological Control Systems -- Foundations of Pharmacodynamic Systems Analysis -- Direct, Indirect, and Signal Transduction Response Modeling -- Irreversible Pharmacodynamics -- Feedback Control Indirect Response Models -- Nonlinear Mixed Effects Modeling in Systems Pharmacology -- Detecting Pharmacokinetic and Pharmacodynamic Covariates From High-Dimensional Data -- Multi-Scale Modeling of Drug Action in the Nervous System -- Mechanistic Modeling of Inflammation -- Systems Pharmacology of Tyrosine Kinase Inhibitor-Associated Toxicities -- Translational Modeling of Antibacterial Agents -- Viral Dynamic Modeling of Hepatitis C Virus Infection: Past Successes and Future Challenges -- Using Systems Pharmacology to Advance Oncology Drug Development -- Systems Pharmacology Modeling in Type 2 Diabetes Mellitus.
Contained By:	Springer eBooks
標題:	Pharmacology. -
電子資源:	http://dx.doi.org/10.1007/978-3-319-44534-2
ISBN:	9783319445342

Systems pharmacology and pharmacodynamics
Systems pharmacology and pharmacodynamics[electronic resource] /edited by Donald E. Mager, Holly H.C. Kimko. - Cham :Springer International Publishing :2016. - xiii, 511 p. :ill., digital ;24 cm. - AAPS advances in the pharmaceutical sciences series,v.232210-7371 ;. - AAPS advances in the pharmaceutical sciences series ;v.23..

Role of Systems Modeling in Regulatory Drug Approval -- Quantitative Systems Pharmacology: Applications and Adoption in Drug Development -- Systems Pharmacology: An Overview -- Discrete dynamic modeling: a network approach for systems pharmacology -- Kinetic Models of Biochemical Signaling Networks -- Mechanistic Models of Physiological Control Systems -- Foundations of Pharmacodynamic Systems Analysis -- Direct, Indirect, and Signal Transduction Response Modeling -- Irreversible Pharmacodynamics -- Feedback Control Indirect Response Models -- Nonlinear Mixed Effects Modeling in Systems Pharmacology -- Detecting Pharmacokinetic and Pharmacodynamic Covariates From High-Dimensional Data -- Multi-Scale Modeling of Drug Action in the Nervous System -- Mechanistic Modeling of Inflammation -- Systems Pharmacology of Tyrosine Kinase Inhibitor-Associated Toxicities -- Translational Modeling of Antibacterial Agents -- Viral Dynamic Modeling of Hepatitis C Virus Infection: Past Successes and Future Challenges -- Using Systems Pharmacology to Advance Oncology Drug Development -- Systems Pharmacology Modeling in Type 2 Diabetes Mellitus.

While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.

ISBN: 9783319445342

Standard No.: 10.1007/978-3-319-44534-2doiSubjects--Topical Terms:

634543
Pharmacology.

LC Class. No.: RM300

Dewey Class. No.: 615.1

Systems pharmacology and pharmacodynamics
LDR:03274nmm a2200325 a 4500 001 2082383
003 DE-He213
005 20161201061725.0
006 m d
007 cr nn 008maaau
008 170717s2016 gw s 0 eng d
020 $a 9783319445342 $q (electronic bk.)
020 $a 9783319445328 $q (paper)
024 7 $a 10.1007/978-3-319-44534-2 $2 doi
035 $a 978-3-319-44534-2
040 $a GP $c GP
041 0 $a eng
050 4 $a RM300
072 7 $a TDCW $2 bicssc
072 7 $a MED072000 $2 bisacsh
082 0 4 $a 615.1 $2 23
090 $a RM300 $b .S995 2016
245 0 0 $a Systems pharmacology and pharmacodynamics $h [electronic resource] / $c edited by Donald E. Mager, Holly H.C. Kimko.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2016.
300 $a xiii, 511 p. : $b ill., digital ; $c 24 cm.
490 1 $a AAPS advances in the pharmaceutical sciences series, $x 2210-7371 ; $v v.23
505 0 $a Role of Systems Modeling in Regulatory Drug Approval -- Quantitative Systems Pharmacology: Applications and Adoption in Drug Development -- Systems Pharmacology: An Overview -- Discrete dynamic modeling: a network approach for systems pharmacology -- Kinetic Models of Biochemical Signaling Networks -- Mechanistic Models of Physiological Control Systems -- Foundations of Pharmacodynamic Systems Analysis -- Direct, Indirect, and Signal Transduction Response Modeling -- Irreversible Pharmacodynamics -- Feedback Control Indirect Response Models -- Nonlinear Mixed Effects Modeling in Systems Pharmacology -- Detecting Pharmacokinetic and Pharmacodynamic Covariates From High-Dimensional Data -- Multi-Scale Modeling of Drug Action in the Nervous System -- Mechanistic Modeling of Inflammation -- Systems Pharmacology of Tyrosine Kinase Inhibitor-Associated Toxicities -- Translational Modeling of Antibacterial Agents -- Viral Dynamic Modeling of Hepatitis C Virus Infection: Past Successes and Future Challenges -- Using Systems Pharmacology to Advance Oncology Drug Development -- Systems Pharmacology Modeling in Type 2 Diabetes Mellitus.
520 $a While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.
650 0 $a Pharmacology. $3 634543
650 0 $a Pharmacokinetics. $3 550960
650 0 $a Systems biology. $3 905904
650 1 4 $a Biomedicine. $3 890831
650 2 4 $a Pharmaceutical Sciences/Technology. $3 1001579
650 2 4 $a Mathematical and Computational Biology. $3 1566274
650 2 4 $a Medical Biochemistry. $3 892387
700 1 $a Mager, Donald E. $3 3205726
700 1 $a Kimko, Holly H.C. $3 3205727
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
830 0 $a AAPS advances in the pharmaceutical sciences series ; $v v.23. $3 3205728
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-44534-2
950 $a Biomedical and Life Sciences (Springer-11642)