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Oral antioxidants for radioprotectio...

Velauthapillai, Nivethan.

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Oral antioxidants for radioprotection during medical imaging examinations.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Oral antioxidants for radioprotection during medical imaging examinations./
Author:	Velauthapillai, Nivethan.
Description:	120 p.
Notes:	Source: Masters Abstracts International, Volume: 55-03.
Contained By:	Masters Abstracts International55-03(E).
Subject:	Medical imaging. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1605856
ISBN:	9781339346229

Oral antioxidants for radioprotection during medical imaging examinations.
Velauthapillai, Nivethan.

Oral antioxidants for radioprotection during medical imaging examinations. - 120 p.

Source: Masters Abstracts International, Volume: 55-03.

Thesis (M.Sc.)--University of Toronto (Canada), 2015.

The oncogenic effect of ionizing radiation (IR) is clearly established and occurs in response to DNA damage. Many diagnostic imaging exams make use of IR and the oncogenic risk of IR-based imaging has been calculated. We hypothesized that the DNA damage sustained from IR exposure during medical imaging exams could be reduced by pre-medicating patients with antioxidants. First, we tested and validated a method for measuring DNA double-strand breaks (DSBs) in peripheral blood mononuclear cells (PBMCs) exposed to low doses of ionizing radiation. Afterwards, we conducted a pilot clinical study in which we administered oral antioxidants to patients undergoing bone scans, prior to radiotracer injection. We showed that oral antioxidant pre-medication reduced the number of DSBs in PBMCs induced by radiotracer injection. Our study shows proof-of-principle for this simple and inexpensive approach to radioprotection in the clinical setting.

ISBN: 9781339346229Subjects--Topical Terms:

3172799
Medical imaging.

Oral antioxidants for radioprotection during medical imaging examinations.
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245 1 0 $a Oral antioxidants for radioprotection during medical imaging examinations.
300 $a 120 p.
500 $a Source: Masters Abstracts International, Volume: 55-03.
500 $a Adviser: David J. Mikulis.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2015.
520 $a The oncogenic effect of ionizing radiation (IR) is clearly established and occurs in response to DNA damage. Many diagnostic imaging exams make use of IR and the oncogenic risk of IR-based imaging has been calculated. We hypothesized that the DNA damage sustained from IR exposure during medical imaging exams could be reduced by pre-medicating patients with antioxidants. First, we tested and validated a method for measuring DNA double-strand breaks (DSBs) in peripheral blood mononuclear cells (PBMCs) exposed to low doses of ionizing radiation. Afterwards, we conducted a pilot clinical study in which we administered oral antioxidants to patients undergoing bone scans, prior to radiotracer injection. We showed that oral antioxidant pre-medication reduced the number of DSBs in PBMCs induced by radiotracer injection. Our study shows proof-of-principle for this simple and inexpensive approach to radioprotection in the clinical setting.
590 $a School code: 0779.
650 4 $a Medical imaging. $3 3172799
650 4 $a Nuclear physics and radiation. $3 3173793
650 4 $a Genetics. $3 530508
650 4 $a Biochemistry. $3 518028
650 4 $a Pharmacology. $3 634543
690 $a 0574
690 $a 0756
690 $a 0369
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690 $a 0419
710 2 $a University of Toronto (Canada). $b Medical Science. $3 3182952
773 0 $t Masters Abstracts International $g 55-03(E).
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791 $a M.Sc.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1605856