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Oral antioxidants for radioprotectio...

Velauthapillai, Nivethan.

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Oral antioxidants for radioprotection during medical imaging examinations.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Oral antioxidants for radioprotection during medical imaging examinations./
作者:	Velauthapillai, Nivethan.
面頁冊數:	120 p.
附註:	Source: Masters Abstracts International, Volume: 55-03.
Contained By:	Masters Abstracts International55-03(E).
標題:	Medical imaging. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1605856
ISBN:	9781339346229

Oral antioxidants for radioprotection during medical imaging examinations.
Velauthapillai, Nivethan.

Oral antioxidants for radioprotection during medical imaging examinations. - 120 p.

Source: Masters Abstracts International, Volume: 55-03.

Thesis (M.Sc.)--University of Toronto (Canada), 2015.

The oncogenic effect of ionizing radiation (IR) is clearly established and occurs in response to DNA damage. Many diagnostic imaging exams make use of IR and the oncogenic risk of IR-based imaging has been calculated. We hypothesized that the DNA damage sustained from IR exposure during medical imaging exams could be reduced by pre-medicating patients with antioxidants. First, we tested and validated a method for measuring DNA double-strand breaks (DSBs) in peripheral blood mononuclear cells (PBMCs) exposed to low doses of ionizing radiation. Afterwards, we conducted a pilot clinical study in which we administered oral antioxidants to patients undergoing bone scans, prior to radiotracer injection. We showed that oral antioxidant pre-medication reduced the number of DSBs in PBMCs induced by radiotracer injection. Our study shows proof-of-principle for this simple and inexpensive approach to radioprotection in the clinical setting.

ISBN: 9781339346229Subjects--Topical Terms:

3172799
Medical imaging.

Oral antioxidants for radioprotection during medical imaging examinations.
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