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Evolution of antiviral breadth in Mx...

Mitchell, Patrick S.

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Evolution of antiviral breadth in Mx GTPases.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Evolution of antiviral breadth in Mx GTPases./
作者:	Mitchell, Patrick S.
面頁冊數:	126 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-08(E), Section: B.
Contained By:	Dissertation Abstracts International76-08B(E).
標題:	Virology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3688946
ISBN:	9781321678857

Evolution of antiviral breadth in Mx GTPases.
Mitchell, Patrick S.

Evolution of antiviral breadth in Mx GTPases. - 126 p.

Source: Dissertation Abstracts International, Volume: 76-08(E), Section: B.

Thesis (Ph.D.)--University of Washington, 2015.

This item is not available from ProQuest Dissertations & Theses.

As obligate parasites, viral pathogens coopt host resources and subvert cellular processes to promote their own replication. In response, host organisms have evolved numerous countermeasures to thwart viral infection. However, the molecular basis for how host antiviral defenses overcome the daunting challenge of viral diversity and the highly adaptive nature of viral pathogens is poorly understood. Viral pathogens and their infected hosts are engaged in a constant battle to gain evolutionary dominance. Such host-virus "arms races" drive the rapid evolution of genes in conflict to gain a fitness advantage through recurrent innovation. Herein, I leverage evolutionary signatures of these adaptive processes to gain insight into molecular mechanisms by which the broad-acting antiviral protein MxA overcomes the challenge of viral pathogen diversity. This evolution-guided approach identified and allowed the characterization of multiple surfaces on MxA that function as independent modules to define target recognition and antiviral specificity. These studies provide an evolutionary and molecular basis for MxA antiviral breadth, and suggest general principles by which cell-intrinsic immunity can tip the balance against rapidly evolving RNA viruses.

ISBN: 9781321678857Subjects--Topical Terms:

642304
Virology.

Evolution of antiviral breadth in Mx GTPases.
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506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a As obligate parasites, viral pathogens coopt host resources and subvert cellular processes to promote their own replication. In response, host organisms have evolved numerous countermeasures to thwart viral infection. However, the molecular basis for how host antiviral defenses overcome the daunting challenge of viral diversity and the highly adaptive nature of viral pathogens is poorly understood. Viral pathogens and their infected hosts are engaged in a constant battle to gain evolutionary dominance. Such host-virus "arms races" drive the rapid evolution of genes in conflict to gain a fitness advantage through recurrent innovation. Herein, I leverage evolutionary signatures of these adaptive processes to gain insight into molecular mechanisms by which the broad-acting antiviral protein MxA overcomes the challenge of viral pathogen diversity. This evolution-guided approach identified and allowed the characterization of multiple surfaces on MxA that function as independent modules to define target recognition and antiviral specificity. These studies provide an evolutionary and molecular basis for MxA antiviral breadth, and suggest general principles by which cell-intrinsic immunity can tip the balance against rapidly evolving RNA viruses.
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