東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Beneficial effects of cranberries on...

Nguyen, Thuy.

FindBook

Google Book

Amazon

博客來

Beneficial effects of cranberries on intestinal health.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Beneficial effects of cranberries on intestinal health./
作者:	Nguyen, Thuy.
面頁冊數:	140 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.
Contained By:	Dissertation Abstracts International76-12B(E).
標題:	Nutrition. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3717427
ISBN:	9781321969054

Beneficial effects of cranberries on intestinal health.
Nguyen, Thuy.

Beneficial effects of cranberries on intestinal health. - 140 p.

Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.

Thesis (Ph.D.)--Washington State University, 2015.

Inflammatory bowel disease is a group of inflammatory symptoms affecting the gastrointestinal tract. Prebiotics are selectively fermentable ingredients that stimulate the growth and/or activity of beneficial gut bacteria. We hypothesize that cranberries can exert prebiotic effects on Lactobacillus plantarum (Lp) and Bifidobacterium longum subsp. infantis (Bi).

ISBN: 9781321969054Subjects--Topical Terms:

517777
Nutrition.

Beneficial effects of cranberries on intestinal health.
LDR:03260nmm a2200325 4500 001 2078169
005 20161122113934.5
008 170521s2015 ||||||||||||||||| ||eng d
020 $a 9781321969054
035 $a (MiAaPQ)AAI3717427
035 $a AAI3717427
040 $a MiAaPQ $c MiAaPQ
100 1 $a Nguyen, Thuy. $3 3193738
245 1 0 $a Beneficial effects of cranberries on intestinal health.
300 $a 140 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.
500 $a Adviser: Meijun Zhu.
502 $a Thesis (Ph.D.)--Washington State University, 2015.
520 $a Inflammatory bowel disease is a group of inflammatory symptoms affecting the gastrointestinal tract. Prebiotics are selectively fermentable ingredients that stimulate the growth and/or activity of beneficial gut bacteria. We hypothesize that cranberries can exert prebiotic effects on Lactobacillus plantarum (Lp) and Bifidobacterium longum subsp. infantis (Bi).
520 $a In experiment 1, Lp and HT-29 colonocytes were co-incubated overnight (10:1) in the presence of cranberry extract (CE) at 0, 0.01, or 0.1 mg proanthocyanidin (PAC)/mL and then stress-induced with 10 ng/mL TNF-alpha for 6h. Combination of Lp and CE downregulated (P<0.05) NFkappaB, COX-2 and IL-1beta gene expression in a dose-dependent manner compared to Lp alone. Lp+0.01 mg PAC/mL decreased (P<0.05) IL-1b, IL-2, IL-4, IL-6 and IL-8, suggesting an enhanced anti-inflammatory effect. Post TNF-alpha stress, the Lp+0.1 mg PAC/mL treatment upregulated (P<0.05) SOD activity and inhibited COX-2 and IL-8, suggesting antioxidant and anti-inflammatory activity.
520 $a In experiment 2, we developed a novel synbiotic mouse diet containing Bi. Colony counts were used to quantify viable Bi throughout the storage period at -80ºC, 4ºC or after 24h at 23ºC. The initial Bi concentration (1.03x109 cfu/d) was maintained for at least 5d when stored at -80ºC. The addition of 3% whole cranberry powder (WCP) and pectin to the mouse diet had no effect on Bi viability. In a 14-d feeding study, the BALB/c mice (6wk old; n=48) consumed 3.73g/d, providing an average intake of 1.48x109 cfu Bi/mouse/d.
520 $a Experiment 3 assessed the effects of feeding WCP on dextran sulfate sodium (DSS)-induced colitis (3% for 7d) in female BALB/c mice (6wk old; n=48). Mice were fed the AIN-93G basal diet (DSS control) or the diet supplemented with 1x109 cfu Bi alone, Bi+1% WCP, or Bi+3% WCP for 21d. Supplementation with Bi alone suppressed (P<0.05) disease activity for 19d compared to DSS control and was further delayed until d 20 after WCP was added, indicating delayed colitis onset. The addition of 1% WCP increased (P<0.05) ZO-1, occludin, claudin-3, and claudin-4. At 3%, WCP increased (P<0.05) claudin-4 and decreased claudin-1, crypt damage, and PGE 2. Overall, WCP delayed colitis onset, alleviated inflammation, improved the gut barrier function and promoted anti-cancer effects.
590 $a School code: 0251.
650 4 $a Nutrition. $3 517777
650 4 $a Food science. $3 3173303
650 4 $a Immunology. $3 611031
690 $a 0570
690 $a 0359
690 $a 0982
710 2 $a Washington State University. $b Food Science. $3 2097454
773 0 $t Dissertation Abstracts International $g 76-12B(E).
790 $a 0251
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3717427