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Effects of Resveratrol Supplements o...

Ren, Jingyan.

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Effects of Resveratrol Supplements on Vascular Health in Postmenopausal Women.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Effects of Resveratrol Supplements on Vascular Health in Postmenopausal Women./
Author:	Ren, Jingyan.
Description:	53 p.
Notes:	Source: Masters Abstracts International, Volume: 55-01.
Contained By:	Masters Abstracts International55-01(E).
Subject:	Nutrition. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1599522
ISBN:	9781339065977

Effects of Resveratrol Supplements on Vascular Health in Postmenopausal Women.
Ren, Jingyan.

Effects of Resveratrol Supplements on Vascular Health in Postmenopausal Women. - 53 p.

Source: Masters Abstracts International, Volume: 55-01.

Thesis (M.S.)--University of California, Davis, 2015.

Data from in vitro and animal models suggest the potential for resveratrol to reduce the risk of the development and progression of certain chronic diseases, including cardiovascular disease. However, the amount of resveratrol used in these studies typically exceeds what is found in the diet. This has led to considerable interest in resveratrol as a supplement, but data in humans with regard to the bioavailability and biological effects of supplemental resveratrol are limited. The current study compared the effects of trans-resveratrol and a resveratrol-arginine conjugate on measures of vascular function in a group of at-risk women. 27 postmenopausal women were randomly assigned to consume either 90 mg of resveratrol as the resveratrol-arginine conjugate (ResArg) or as trans-resveratrol (t-Res), a minimum of one week apart. Microvascular function was measured by peripheral arterial tonometry before and two hours after the intake of each supplement. Two indices were calculated: the reactive hyperemia index (RHI) and the Framingham reactive hyperemia index (FRHI). Neither trans-resveratrol nor resveratrol-arginine conjugate supplementation resulted in significant changes in RHI two hours after intake (t-Res: 0h: 2.51 +/- 0.13; 2h: 2.40 +/- 0.12; p=0.45; ResArg: 0h: 2.08 +/- 0.13; 2h: 2.38 +/- 0.12; p= 0.09), however both trans-resveratrol and resveratrol-arginine conjugate supplementation resulted in significant changes in FRHI two hours after intake (t-Res: 0h, 0.85 +/- 0.07; 2h, 0.96 +/- 0.05; p=0.01; ResArg: 0h, 0.67 +/- 0.08; 2h, 0.88 +/- 0.05; p=0.02). No significant differences were observed between the trans-resveratrol and resveratrol-arginine conjugate supplement groups for changes from baseline values for either the RHI (t-Res: -0.11 +/- 0.16; ResArg: 0.31 +/- 0.17; p= 0.22) or the FRHI (t-Res: 0.11 +/- 0.04; ResArg: 0.22 +/- 0.08; p=0.25). Both trans-resveratrol and resveratrol-arginine conjugate supplementation may improve vascular function two hours after intake, however the changes in vascular function between two supplementations were not significantly different. Based on a previous 1 hour study, our results suggest a relatively short time period of action of the resveratrol-arginine conjugate on vascular function. Improvements in vascular function tended to be more pronounced with the resveratrol-arginine conjugate compared to trans-resveratrol.

ISBN: 9781339065977Subjects--Topical Terms:

517777
Nutrition.

Effects of Resveratrol Supplements on Vascular Health in Postmenopausal Women.
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245 1 0 $a Effects of Resveratrol Supplements on Vascular Health in Postmenopausal Women.
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500 $a Source: Masters Abstracts International, Volume: 55-01.
500 $a Adviser: Robert M. Hackman.
502 $a Thesis (M.S.)--University of California, Davis, 2015.
520 $a Data from in vitro and animal models suggest the potential for resveratrol to reduce the risk of the development and progression of certain chronic diseases, including cardiovascular disease. However, the amount of resveratrol used in these studies typically exceeds what is found in the diet. This has led to considerable interest in resveratrol as a supplement, but data in humans with regard to the bioavailability and biological effects of supplemental resveratrol are limited. The current study compared the effects of trans-resveratrol and a resveratrol-arginine conjugate on measures of vascular function in a group of at-risk women. 27 postmenopausal women were randomly assigned to consume either 90 mg of resveratrol as the resveratrol-arginine conjugate (ResArg) or as trans-resveratrol (t-Res), a minimum of one week apart. Microvascular function was measured by peripheral arterial tonometry before and two hours after the intake of each supplement. Two indices were calculated: the reactive hyperemia index (RHI) and the Framingham reactive hyperemia index (FRHI). Neither trans-resveratrol nor resveratrol-arginine conjugate supplementation resulted in significant changes in RHI two hours after intake (t-Res: 0h: 2.51 +/- 0.13; 2h: 2.40 +/- 0.12; p=0.45; ResArg: 0h: 2.08 +/- 0.13; 2h: 2.38 +/- 0.12; p= 0.09), however both trans-resveratrol and resveratrol-arginine conjugate supplementation resulted in significant changes in FRHI two hours after intake (t-Res: 0h, 0.85 +/- 0.07; 2h, 0.96 +/- 0.05; p=0.01; ResArg: 0h, 0.67 +/- 0.08; 2h, 0.88 +/- 0.05; p=0.02). No significant differences were observed between the trans-resveratrol and resveratrol-arginine conjugate supplement groups for changes from baseline values for either the RHI (t-Res: -0.11 +/- 0.16; ResArg: 0.31 +/- 0.17; p= 0.22) or the FRHI (t-Res: 0.11 +/- 0.04; ResArg: 0.22 +/- 0.08; p=0.25). Both trans-resveratrol and resveratrol-arginine conjugate supplementation may improve vascular function two hours after intake, however the changes in vascular function between two supplementations were not significantly different. Based on a previous 1 hour study, our results suggest a relatively short time period of action of the resveratrol-arginine conjugate on vascular function. Improvements in vascular function tended to be more pronounced with the resveratrol-arginine conjugate compared to trans-resveratrol.
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