東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Fighting cancer with nanomedicine---...

Yin, Qian.

FindBook

Google Book

Amazon

博客來

Fighting cancer with nanomedicine---drug-polyester nanoconjugates for targeted cancer therapy.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Fighting cancer with nanomedicine---drug-polyester nanoconjugates for targeted cancer therapy./
作者:	Yin, Qian.
面頁冊數:	196 p.
附註:	Source: Dissertation Abstracts International, Volume: 77-05(E), Section: B.
Contained By:	Dissertation Abstracts International77-05B(E).
標題:	Nanotechnology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3740591
ISBN:	9781339327082

Fighting cancer with nanomedicine---drug-polyester nanoconjugates for targeted cancer therapy.
Yin, Qian.

Fighting cancer with nanomedicine---drug-polyester nanoconjugates for targeted cancer therapy. - 196 p.

Source: Dissertation Abstracts International, Volume: 77-05(E), Section: B.

Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2015.

The aim of my Ph. D. research is to develop drug-polyester nanoconjugates (NCs) as a novel translational polymeric drug delivery system that can successfully evade non-specific uptake by reticuloendothelial system (RES) and facilitate targeted cancer diagnosis and therapy. By uniquely integrating well-established chemical reaction-controlled ring opening polymerization (ROP) with nanoprecipitation technique, I successfully developed a polymeric NC system based on poly(lactic acid) and poly(O-carboxyanhydrides) (OCA) that allows for the quantitative loading and controlled release of a variety of anticancer drugs. The developed NC system could be easily modified with parmidronate, one of bisphosphonates commonly used as the treatment for disease characterized by osteolysis, to selectively deliver doxorubicin (Doxo) to the bone tissues and substantially to improve their therapeutic efficiency in inhibiting the growth of osteosarcoma in both murine and canine models. More importantly, the developed NCs could avidly bind to human serum albumin, a ubiquitous protein in the blood, to bypass the endothelium barrier and penetrate into tumor tissues more deeply and efficiently. When compared with PEGylated NCs, these albumin-bound NCs showed significantly reduced accumulation in RES and enhanced tumor accumulation, which consequently contributed to higher their tumor inhibition capabilities. In addition, the developed NC system allows easy incorporation of X-ray computed tomography (CT) contrast agents to largely facilitate personalized therapy by improving diagnosis accuracy and monitoring therapeutic efficacy. Through the synthetic and formulation strategy I developed, a large quantity (grams or larger-scale) of drug-polyester NCs can be easily obtained, which can be used as a model drug delivery system for fundamental studies as well as a real drug delivery system for disease treatment in clinical settings.

ISBN: 9781339327082Subjects--Topical Terms:

526235
Nanotechnology.

Fighting cancer with nanomedicine---drug-polyester nanoconjugates for targeted cancer therapy.
LDR:02883nmm a2200301 4500 001 2077678
005 20161114130341.5
008 170521s2015 ||||||||||||||||| ||eng d
020 $a 9781339327082
035 $a (MiAaPQ)AAI3740591
035 $a AAI3740591
040 $a MiAaPQ $c MiAaPQ
100 1 $a Yin, Qian. $3 3193202
245 1 0 $a Fighting cancer with nanomedicine---drug-polyester nanoconjugates for targeted cancer therapy.
300 $a 196 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-05(E), Section: B.
500 $a Adviser: Jianjun Cheng.
502 $a Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 2015.
520 $a The aim of my Ph. D. research is to develop drug-polyester nanoconjugates (NCs) as a novel translational polymeric drug delivery system that can successfully evade non-specific uptake by reticuloendothelial system (RES) and facilitate targeted cancer diagnosis and therapy. By uniquely integrating well-established chemical reaction-controlled ring opening polymerization (ROP) with nanoprecipitation technique, I successfully developed a polymeric NC system based on poly(lactic acid) and poly(O-carboxyanhydrides) (OCA) that allows for the quantitative loading and controlled release of a variety of anticancer drugs. The developed NC system could be easily modified with parmidronate, one of bisphosphonates commonly used as the treatment for disease characterized by osteolysis, to selectively deliver doxorubicin (Doxo) to the bone tissues and substantially to improve their therapeutic efficiency in inhibiting the growth of osteosarcoma in both murine and canine models. More importantly, the developed NCs could avidly bind to human serum albumin, a ubiquitous protein in the blood, to bypass the endothelium barrier and penetrate into tumor tissues more deeply and efficiently. When compared with PEGylated NCs, these albumin-bound NCs showed significantly reduced accumulation in RES and enhanced tumor accumulation, which consequently contributed to higher their tumor inhibition capabilities. In addition, the developed NC system allows easy incorporation of X-ray computed tomography (CT) contrast agents to largely facilitate personalized therapy by improving diagnosis accuracy and monitoring therapeutic efficacy. Through the synthetic and formulation strategy I developed, a large quantity (grams or larger-scale) of drug-polyester NCs can be easily obtained, which can be used as a model drug delivery system for fundamental studies as well as a real drug delivery system for disease treatment in clinical settings.
590 $a School code: 0090.
650 4 $a Nanotechnology. $3 526235
650 4 $a Chemical engineering. $3 560457
650 4 $a Oncology. $3 751006
650 4 $a Pharmaceutical sciences. $3 3173021
690 $a 0652
690 $a 0542
690 $a 0992
690 $a 0572
710 2 $a University of Illinois at Urbana-Champaign. $b Materials Science & Engineerng. $3 3178439
773 0 $t Dissertation Abstracts International $g 77-05B(E).
790 $a 0090
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3740591