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An anatomical and developmental anal...

Lovick, Jennifer Kelly.

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An anatomical and developmental analysis of neural lineages, the fundamental units of circuitry in the central brain of Drosophila melanogaster.

Record Type:	Electronic resources : Monograph/item
Title/Author:	An anatomical and developmental analysis of neural lineages, the fundamental units of circuitry in the central brain of Drosophila melanogaster./
Author:	Lovick, Jennifer Kelly.
Description:	199 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-04(E), Section: B.
Contained By:	Dissertation Abstracts International77-04B(E).
Subject:	Developmental biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3737520
ISBN:	9781339270326

An anatomical and developmental analysis of neural lineages, the fundamental units of circuitry in the central brain of Drosophila melanogaster.
Lovick, Jennifer Kelly.

An anatomical and developmental analysis of neural lineages, the fundamental units of circuitry in the central brain of Drosophila melanogaster. - 199 p.

Source: Dissertation Abstracts International, Volume: 77-04(E), Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2015.

This work examines a variety of fundamental biological questions regarding the.

ISBN: 9781339270326Subjects--Topical Terms:

592588
Developmental biology.

An anatomical and developmental analysis of neural lineages, the fundamental units of circuitry in the central brain of Drosophila melanogaster.
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020 $a 9781339270326
035 $a (MiAaPQ)AAI3737520
035 $a AAI3737520
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100 1 $a Lovick, Jennifer Kelly. $3 3193157
245 1 3 $a An anatomical and developmental analysis of neural lineages, the fundamental units of circuitry in the central brain of Drosophila melanogaster.
300 $a 199 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-04(E), Section: B.
500 $a Adviser: Volker Hartenstein.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2015.
520 $a This work examines a variety of fundamental biological questions regarding the.
520 $a central brain of D. melanogaster. These questions focus on topics relating to neurons.
520 $a which form the neural circuits of the larval and adult brain. We focused specifically on.
520 $a the neurons which form the central brain and are organized into developmental-structural units termed lineages. Through a combination of genetics and.
520 $a immunohistochemical assays we were able to create a detailed atlas of lineages in the.
520 $a early larval brain (made by embryonic-born primary neurons) and the adult brain (made.
520 $a mostly by larval-born secondary neurons; Chapters 2 and 6); show that secondary.
520 $a lineages are born in a strict temporal manner and how they develop during larval and.
520 $a pupal stages (Chapters 3-5). By observing secondary lineages in both wild-type and.
520 $a various mutant conditions we were able to show the following: pattern and timing of.
520 $a secondary lineage axon tract extension in the larva; movement of cell body clusters due.
520 $a to the growing central brain and optic lobe neuropils during metamorphosis; which.
520 $a secondary lineages retain their entire cohort of neurons (many lose a hemilineage in the.
520 $a pupa); and proper differentiation of secondary lineages relies on the presence of both.
520 $a synaptic partners. Taken together, these studies make a significant contribution to our.
520 $a understanding of Drosophila brain circuitry and development. They support the overall.
520 $a goal of mapping all central brain lineages (primary and secondary components), from.
520 $a their inception in the early embryo (when neuroblasts first appear) to their final mature.
520 $a form in the adult.
590 $a School code: 0031.
650 4 $a Developmental biology. $3 592588
650 4 $a Neurosciences. $3 588700
650 4 $a Genetics. $3 530508
690 $a 0758
690 $a 0317
690 $a 0369
710 2 $a University of California, Los Angeles. $b Molecular, Cell, and Developmental Biology. $3 3193158
773 0 $t Dissertation Abstracts International $g 77-04B(E).
790 $a 0031
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3737520