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Applications of Digital Microfluidic...

Lafreniere, Nelson Mario.

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Applications of Digital Microfluidics for the Extraction and Analysis of Small Molecules from Solid Samples.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Applications of Digital Microfluidics for the Extraction and Analysis of Small Molecules from Solid Samples./
Author:	Lafreniere, Nelson Mario.
Description:	131 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.
Contained By:	Dissertation Abstracts International76-12B(E).
Subject:	Analytical chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3717539
ISBN:	9781321970425

Applications of Digital Microfluidics for the Extraction and Analysis of Small Molecules from Solid Samples.
Lafreniere, Nelson Mario.

Applications of Digital Microfluidics for the Extraction and Analysis of Small Molecules from Solid Samples. - 131 p.

Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.

Thesis (Ph.D.)--University of Toronto (Canada), 2015.

Digital microfluidics (DMF) has emerged as a valuable technology that may be useful in the goal of realizing true lab-on-a-chip (LOC) or total micro analysis systems (muTAS). DMF is a relatively new microscale liquid-handling technique in which droplets of fluid are manipulated on a flat, two-dimensional array of electrodes coated with a hydrophobic insulator. Droplet movement is driven by the application of electric potentials to successive electrodes, enabling a droplet to be dispensed from a reservoir, merged, mixed and split. One of the strengths of DMF when compared to channel microfluidics is the ease with which DMF can process solid samples, and incorporate solid materials into sample preparation work-flows without the risk of clogging.

ISBN: 9781321970425Subjects--Topical Terms:

3168300
Analytical chemistry.

Applications of Digital Microfluidics for the Extraction and Analysis of Small Molecules from Solid Samples.
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100 1 $a Lafreniere, Nelson Mario. $3 3193046
245 1 0 $a Applications of Digital Microfluidics for the Extraction and Analysis of Small Molecules from Solid Samples.
300 $a 131 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.
500 $a Adviser: Aaron R. Wheeler.
502 $a Thesis (Ph.D.)--University of Toronto (Canada), 2015.
520 $a Digital microfluidics (DMF) has emerged as a valuable technology that may be useful in the goal of realizing true lab-on-a-chip (LOC) or total micro analysis systems (muTAS). DMF is a relatively new microscale liquid-handling technique in which droplets of fluid are manipulated on a flat, two-dimensional array of electrodes coated with a hydrophobic insulator. Droplet movement is driven by the application of electric potentials to successive electrodes, enabling a droplet to be dispensed from a reservoir, merged, mixed and split. One of the strengths of DMF when compared to channel microfluidics is the ease with which DMF can process solid samples, and incorporate solid materials into sample preparation work-flows without the risk of clogging.
520 $a This thesis describes the exploration of digital microfluidics as a tool for working with solid samples and matrices. Chapter two describes the first method useful for analyzing multiple hormones in dried blood. This method broadens the scope and breadth of information available from the analysis of dried blood spotted directly onto device. Chapter three describes the first method for applying digital microfluidics towards the analysis of pharmaceuticals from blood spotted onto filter paper -- dried blood spots (DBS). The DMF method is compared to the traditional macroscale method employed by collaborators at GlaxoSmithKline. Chapter four describes the first combination of DMF and miniature mass spectrometry (MS). This newly developed, automated, multiplexed, and portable platform was designed for the extraction of illicit drugs from dried urine, and is designed to replace the traditional two-tiered urine analysis system with a one-tiered total analysis system. Chapter five describes a new method for on-chip solvent optimization using a design of experiment. Using this system, C18-coated magnetic beads were incorporated onto device, enabling the first instance of fractionation on a DMF device. Finally, chapter six summarizes the principles and concepts derived from this work, and concludes with a look forward to future applications of digital microfluidics as a tool to handle solid samples and matrices.
590 $a School code: 0779.
650 4 $a Analytical chemistry. $3 3168300
650 4 $a Biochemistry. $3 518028
650 4 $a Cellular biology. $3 3172791
650 4 $a Molecular biology. $3 517296
650 4 $a Oncology. $3 751006
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710 2 $a University of Toronto (Canada). $b Chemistry. $3 3178441
773 0 $t Dissertation Abstracts International $g 76-12B(E).
790 $a 0779
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3717539