東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Changes in behavioral effects of del...

Coker, Allison.

Linked to FindBook

Google Book

Amazon

博客來

Changes in behavioral effects of delta opioid receptor agonists with ethanol consumption.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Changes in behavioral effects of delta opioid receptor agonists with ethanol consumption./
Author:	Coker, Allison.
Description:	95 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.
Contained By:	Dissertation Abstracts International76-11B(E).
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3712203
ISBN:	9781321888676

Changes in behavioral effects of delta opioid receptor agonists with ethanol consumption.
Coker, Allison.

Changes in behavioral effects of delta opioid receptor agonists with ethanol consumption. - 95 p.

Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.

Thesis (Ph.D.)--University of California, San Francisco, 2015.

Alcohol use disorders (AUDs) are a common problem with few effective treatment options. There are only three FDA-approved drugs for the treatment of AUDs, all of which show limited treatment efficacy and none alleviate comorbid anxiety and/or depression. Thus, there is a significant need to identify novel targets for the treatment of AUDs, and the delta opioid receptor (DOR) could represent such a target. DOR agonists have been demonstrated to reduce EtOH consumption in rodent models and have well-established roles in motivation and anxiety. Importantly, the expression and function of DORs are known to change dynamically with a variety of perturbations including EtOH exposure, stress, and pain. This manuscript examines some ways in which the DOR regulation of reward and anxiety behaviors changes with behavioral state. We examined the preference to the DOR-1 agonist DPDPE and the DOR-2 agonist deltorphin in the conditioned place preference paradigm in animals that were either naive or ethanol consuming, as well as either stressed or un-stressed. While neither DPDPE nor deltorphin induced a place preference in naive unstressed animals, deltorphin induced a significant place preference in unstressed ethanol consuming animals. In stressed animals, DPDPE does not induce a place preference whether or not the animals were consuming ethanol. In contrast, deltorphin induces a place preference in ethanol naive stressed animals, however not in animals that were both stressed and ethanol consuming. We also examined the effects of the DOR-1 agonist TAN 67 and the DOR-2 agonist SNC 80 on anxiety-like behavior measured by the marble burying task in both naive and ethanol consuming animals. We found that while SNC 80 showed anxiolytic-like effects in naive animals, TAN 67 did not. However, neither DOR agonist showed an anxiolytic-like effect in ethanol consuming animals. This is in contrast to previous findings with the light/dark transition test in which DOR agonists increased anxiolytic efficacy with ethanol consumption. Together these studies examine DOR effects on reward and anxiety behaviors and further our understanding of how the effects of DOR agonists are dynamically changed by physiological state to help to refine targets for therapeutic development.

ISBN: 9781321888676Subjects--Topical Terms:

588700
Neurosciences.

Changes in behavioral effects of delta opioid receptor agonists with ethanol consumption.
LDR:03229nmm a2200301 4500 001 2077518
005 20161114130322.5
008 170521s2015 ||||||||||||||||| ||eng d
020 $a 9781321888676
035 $a (MiAaPQ)AAI3712203
035 $a AAI3712203
040 $a MiAaPQ $c MiAaPQ
100 1 $a Coker, Allison. $3 3193027
245 1 0 $a Changes in behavioral effects of delta opioid receptor agonists with ethanol consumption.
300 $a 95 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.
500 $a Adviser: Jennifer Whistler.
502 $a Thesis (Ph.D.)--University of California, San Francisco, 2015.
520 $a Alcohol use disorders (AUDs) are a common problem with few effective treatment options. There are only three FDA-approved drugs for the treatment of AUDs, all of which show limited treatment efficacy and none alleviate comorbid anxiety and/or depression. Thus, there is a significant need to identify novel targets for the treatment of AUDs, and the delta opioid receptor (DOR) could represent such a target. DOR agonists have been demonstrated to reduce EtOH consumption in rodent models and have well-established roles in motivation and anxiety. Importantly, the expression and function of DORs are known to change dynamically with a variety of perturbations including EtOH exposure, stress, and pain. This manuscript examines some ways in which the DOR regulation of reward and anxiety behaviors changes with behavioral state. We examined the preference to the DOR-1 agonist DPDPE and the DOR-2 agonist deltorphin in the conditioned place preference paradigm in animals that were either naive or ethanol consuming, as well as either stressed or un-stressed. While neither DPDPE nor deltorphin induced a place preference in naive unstressed animals, deltorphin induced a significant place preference in unstressed ethanol consuming animals. In stressed animals, DPDPE does not induce a place preference whether or not the animals were consuming ethanol. In contrast, deltorphin induces a place preference in ethanol naive stressed animals, however not in animals that were both stressed and ethanol consuming. We also examined the effects of the DOR-1 agonist TAN 67 and the DOR-2 agonist SNC 80 on anxiety-like behavior measured by the marble burying task in both naive and ethanol consuming animals. We found that while SNC 80 showed anxiolytic-like effects in naive animals, TAN 67 did not. However, neither DOR agonist showed an anxiolytic-like effect in ethanol consuming animals. This is in contrast to previous findings with the light/dark transition test in which DOR agonists increased anxiolytic efficacy with ethanol consumption. Together these studies examine DOR effects on reward and anxiety behaviors and further our understanding of how the effects of DOR agonists are dynamically changed by physiological state to help to refine targets for therapeutic development.
590 $a School code: 0034.
650 4 $a Neurosciences. $3 588700
650 4 $a Mental health. $3 534751
650 4 $a Clinical psychology. $3 524863
650 4 $a Pharmacology. $3 634543
690 $a 0317
690 $a 0347
690 $a 0622
690 $a 0419
710 2 $a University of California, San Francisco. $b Neuroscience. $3 1267784
773 0 $t Dissertation Abstracts International $g 76-11B(E).
790 $a 0034
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3712203