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Investigations into Context-Dependen...

Kornacki, James R.

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Investigations into Context-Dependent Histone Modification by SAMDI Mass Spectrometry.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Investigations into Context-Dependent Histone Modification by SAMDI Mass Spectrometry./
作者:	Kornacki, James R.
面頁冊數:	183 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-10(E), Section: B.
Contained By:	Dissertation Abstracts International76-10B(E).
標題:	Analytical chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3705294
ISBN:	9781321781984

Investigations into Context-Dependent Histone Modification by SAMDI Mass Spectrometry.
Kornacki, James R.

Investigations into Context-Dependent Histone Modification by SAMDI Mass Spectrometry. - 183 p.

Source: Dissertation Abstracts International, Volume: 76-10(E), Section: B.

Thesis (Ph.D.)--Northwestern University, 2015.

Epigenetics is directed, in part, by the regulated placement and removal of covalent histone post-translational modifications. Patterns of histone post-translational modification regulate access to the associated genome via interactions with protein complexes, which then direct transcriptional fate. This process is established and maintained by the "writing, reading, and erasing" of covalent modifications through the action of histone-modifying enzymes. In this work, I present novel mechanisms of histone modification crosstalk -- a form of enzymatic communication. I also illustrate the powerful influence of selective small molecule modulators. Both emphasize the recurrent theme that histone post-translational modification is highly context-dependent.

ISBN: 9781321781984Subjects--Topical Terms:

3168300
Analytical chemistry.

Investigations into Context-Dependent Histone Modification by SAMDI Mass Spectrometry.
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