語系:
繁體中文
English
說明(常見問題)
回圖書館首頁
手機版館藏查詢
登入
回首頁
切換:
標籤
|
MARC模式
|
ISBD
The Development and Implementation o...
~
Schubert, Stephanie Mae.
FindBook
Google Book
Amazon
博客來
The Development and Implementation of Single Molecule Protein Assays for Applications in Early Cancer Diagnostics and Single Cell Studies.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
The Development and Implementation of Single Molecule Protein Assays for Applications in Early Cancer Diagnostics and Single Cell Studies./
作者:
Schubert, Stephanie Mae.
面頁冊數:
172 p.
附註:
Source: Dissertation Abstracts International, Volume: 76-10(E), Section: B.
Contained By:
Dissertation Abstracts International76-10B(E).
標題:
Chemistry. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3704617
ISBN:
9781321771725
The Development and Implementation of Single Molecule Protein Assays for Applications in Early Cancer Diagnostics and Single Cell Studies.
Schubert, Stephanie Mae.
The Development and Implementation of Single Molecule Protein Assays for Applications in Early Cancer Diagnostics and Single Cell Studies.
- 172 p.
Source: Dissertation Abstracts International, Volume: 76-10(E), Section: B.
Thesis (Ph.D.)--Tufts University, 2015.
Earlier detection of diseases, such as cancer, often leads to improved prognosis. Therefore, the ability to efficiently, accurately, sensitively, and non-invasively screen for cancer at the earliest stages possible is of paramount importance. Furthermore, a better understanding of the basic biology of molecular mechanisms, cellular pathways, and cellular heterogeneity may lead to more personalized and efficient therapies. In order to achieve this task and to also detect rare cells that may also enable earlier disease detection, specific biomarkers must be studied at single molecule resolution within individual cells. This thesis focuses on the detection of protein biomarkers at ultralow levels in serum for early cancer detection and for fundamental single cell studies using single molecule protein counting technology.
ISBN: 9781321771725Subjects--Topical Terms:
516420
Chemistry.
The Development and Implementation of Single Molecule Protein Assays for Applications in Early Cancer Diagnostics and Single Cell Studies.
LDR
:02734nmm a2200289 4500
001
2077468
005
20161114130316.5
008
170521s2015 ||||||||||||||||| ||eng d
020
$a
9781321771725
035
$a
(MiAaPQ)AAI3704617
035
$a
AAI3704617
040
$a
MiAaPQ
$c
MiAaPQ
100
1
$a
Schubert, Stephanie Mae.
$3
3192971
245
1 4
$a
The Development and Implementation of Single Molecule Protein Assays for Applications in Early Cancer Diagnostics and Single Cell Studies.
300
$a
172 p.
500
$a
Source: Dissertation Abstracts International, Volume: 76-10(E), Section: B.
500
$a
Adviser: David R. Walt.
502
$a
Thesis (Ph.D.)--Tufts University, 2015.
520
$a
Earlier detection of diseases, such as cancer, often leads to improved prognosis. Therefore, the ability to efficiently, accurately, sensitively, and non-invasively screen for cancer at the earliest stages possible is of paramount importance. Furthermore, a better understanding of the basic biology of molecular mechanisms, cellular pathways, and cellular heterogeneity may lead to more personalized and efficient therapies. In order to achieve this task and to also detect rare cells that may also enable earlier disease detection, specific biomarkers must be studied at single molecule resolution within individual cells. This thesis focuses on the detection of protein biomarkers at ultralow levels in serum for early cancer detection and for fundamental single cell studies using single molecule protein counting technology.
520
$a
This thesis describes the technology, single molecule arrays (SiMoA), that is utilized throughout the included works and discusses the fundamental kinetics behind the method. Chapter 3 describes how a biomarker can be detected at ultralow concentrations in serum prior to palpable tumor formation using a mouse model, indicating the utility of SiMoA as an early cancer detection tool. Chapter 4 describes the use of SiMoA in a panel of breast cancer protein biomarkers and examines the utility of these biomarkers in detecting early stage breast cancer from serum samples by using supervised multivariate regression models. Chapter 5 demonstrates the use of SiMoA technology as a straightforward approach for counting single protein molecules within single cells. Chapter 6 includes work towards creating a breast cancer mouse model for studying early cancer progression. One appendix is included that includes detailed patient information relevant to Chapter 4.
590
$a
School code: 0234.
650
4
$a
Chemistry.
$3
516420
650
4
$a
Analytical chemistry.
$3
3168300
690
$a
0485
690
$a
0486
710
2
$a
Tufts University.
$b
Chemistry.
$3
1058685
773
0
$t
Dissertation Abstracts International
$g
76-10B(E).
790
$a
0234
791
$a
Ph.D.
792
$a
2015
793
$a
English
856
4 0
$u
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3704617
筆 0 讀者評論
館藏地:
全部
電子資源
出版年:
卷號:
館藏
1 筆 • 頁數 1 •
1
條碼號
典藏地名稱
館藏流通類別
資料類型
索書號
使用類型
借閱狀態
預約狀態
備註欄
附件
W9310336
電子資源
11.線上閱覽_V
電子書
EB
一般使用(Normal)
在架
0
1 筆 • 頁數 1 •
1
多媒體
評論
新增評論
分享你的心得
Export
取書館
處理中
...
變更密碼
登入