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Pathogen avoidance by Caenorhabditis...

Nowojewski, Andrzej Kazimierz.

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Pathogen avoidance by Caenorhabditis elegans is a pheromone-mediated collective behavior.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Pathogen avoidance by Caenorhabditis elegans is a pheromone-mediated collective behavior./
Author:	Nowojewski, Andrzej Kazimierz.
Description:	118 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.
Contained By:	Dissertation Abstracts International76-09B(E).
Subject:	Biophysics. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3700557
ISBN:	9781321705515

Pathogen avoidance by Caenorhabditis elegans is a pheromone-mediated collective behavior.
Nowojewski, Andrzej Kazimierz.

Pathogen avoidance by Caenorhabditis elegans is a pheromone-mediated collective behavior. - 118 p.

Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.

Thesis (Ph.D.)--Harvard University, 2015.

A model organism Caenorhabditis elegans is a free-living nematode that feeds on bacteria in the wild. To survive, it has to be able to distinguish between benign and pathogenic microorganisms. Thanks to its simple neural system it is capable of determining whether the source of food is dangerous and physically avoid it.

ISBN: 9781321705515Subjects--Topical Terms:

518360
Biophysics.

Pathogen avoidance by Caenorhabditis elegans is a pheromone-mediated collective behavior.
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100 1 $a Nowojewski, Andrzej Kazimierz. $3 3192955
245 1 0 $a Pathogen avoidance by Caenorhabditis elegans is a pheromone-mediated collective behavior.
300 $a 118 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.
500 $a Advisers: Erel Levine; Mara Prentiss; Aravinthan Samuel.
502 $a Thesis (Ph.D.)--Harvard University, 2015.
520 $a A model organism Caenorhabditis elegans is a free-living nematode that feeds on bacteria in the wild. To survive, it has to be able to distinguish between benign and pathogenic microorganisms. Thanks to its simple neural system it is capable of determining whether the source of food is dangerous and physically avoid it.
520 $a In this work we present evidence that this avoidance behavior depends on the nematode population density. The worms exposed to a pathogen secrete an alarm pheromone, which drives the population away from the danger. Worms carrying a mutation in the acox-1 gene (involved in the pheromone biosynthesis) are unable to produce the alarm signal and odr-7 mutants fail to react to it suggesting that AWA neurons are involved in the pheromone detection. We developed a simple phenomenological model that quantifies the effects of the secreted pheromone and was able to reproduce major features of the nematodes' behavior at the population level.
520 $a We show that the collective avoidance is not restricted to C. elegans as other Rhabditida nematodes also exhibit this behavior. Furthermore, the alarm signal left by C. elegans in the bacterial lawn is detected by most of the other species tested but some of them were attracted to it rather than repulsed which suggests that the chemical signal is not conserved between them.
590 $a School code: 0084.
650 4 $a Biophysics. $3 518360
650 4 $a Behavioral sciences. $3 529833
650 4 $a Microbiology. $3 536250
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710 2 $a Harvard University. $b Physics. $3 2094825
773 0 $t Dissertation Abstracts International $g 76-09B(E).
790 $a 0084
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3700557