東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Cortical Representations Are Reinsta...

Tanaka, Kazumasa.

Linked to FindBook

Google Book

Amazon

博客來

Cortical Representations Are Reinstated By The Hippocampus During Memory Retrieval.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Cortical Representations Are Reinstated By The Hippocampus During Memory Retrieval./
Author:	Tanaka, Kazumasa.
Description:	122 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-04(E), Section: B.
Contained By:	Dissertation Abstracts International77-04B(E).
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3737018
ISBN:	9781339260983

Cortical Representations Are Reinstated By The Hippocampus During Memory Retrieval.
Tanaka, Kazumasa.

Cortical Representations Are Reinstated By The Hippocampus During Memory Retrieval. - 122 p.

Source: Dissertation Abstracts International, Volume: 77-04(E), Section: B.

Thesis (Ph.D.)--University of California, Davis, 2015.

The hippocampus is assumed to retrieve memory by reinstating patterns of cortical activity that were observed during learning. To test this long-standing idea, we used modern genetic tools to monitor the activity of individual cortical neurons while simultaneously inactivating the hippocampus. Neurons that were active during context fear conditioning were tagged with the long-lasting fluorescent protein H2B-GFP and the light activated proton pump ArchT-GFP. These proteins allowed us to identify encoding neurons several days after learning and silence them with laser stimulation. When tagged CA1 cells were silenced, we found that memory retrieval was severely impaired and representations in the cortex (subiculum, entorhinal, retrosplenial, perirhinal) and the amygdala could not be reactivated. Importantly, hippocampal inactivation did not alter the total amount of activity in most brain regions. Instead, it selectively prevented neurons that were active during learning from being reactivated during retrieval. These data provide functional evidence for the assumption that the hippocampus reactivates specific memory representations during retrieval.

ISBN: 9781339260983Subjects--Topical Terms:

588700
Neurosciences.

Cortical Representations Are Reinstated By The Hippocampus During Memory Retrieval.
LDR:02074nmm a2200289 4500 001 2076431
005 20161028121127.5
008 170521s2015 ||||||||||||||||| ||eng d
020 $a 9781339260983
035 $a (MiAaPQ)AAI3737018
035 $a AAI3737018
040 $a MiAaPQ $c MiAaPQ
100 1 $a Tanaka, Kazumasa. $3 3191887
245 1 0 $a Cortical Representations Are Reinstated By The Hippocampus During Memory Retrieval.
300 $a 122 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-04(E), Section: B.
500 $a Adviser: Brian J. Wiltgen.
502 $a Thesis (Ph.D.)--University of California, Davis, 2015.
520 $a The hippocampus is assumed to retrieve memory by reinstating patterns of cortical activity that were observed during learning. To test this long-standing idea, we used modern genetic tools to monitor the activity of individual cortical neurons while simultaneously inactivating the hippocampus. Neurons that were active during context fear conditioning were tagged with the long-lasting fluorescent protein H2B-GFP and the light activated proton pump ArchT-GFP. These proteins allowed us to identify encoding neurons several days after learning and silence them with laser stimulation. When tagged CA1 cells were silenced, we found that memory retrieval was severely impaired and representations in the cortex (subiculum, entorhinal, retrosplenial, perirhinal) and the amygdala could not be reactivated. Importantly, hippocampal inactivation did not alter the total amount of activity in most brain regions. Instead, it selectively prevented neurons that were active during learning from being reactivated during retrieval. These data provide functional evidence for the assumption that the hippocampus reactivates specific memory representations during retrieval.
590 $a School code: 0029.
650 4 $a Neurosciences. $3 588700
650 4 $a Cognitive psychology. $3 523881
650 4 $a Psychobiology. $3 555678
690 $a 0317
690 $a 0633
690 $a 0349
710 2 $a University of California, Davis. $b Psychology. $3 2100827
773 0 $t Dissertation Abstracts International $g 77-04B(E).
790 $a 0029
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3737018