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Amygdala Stimulation Enhances Memory...

Bass, David I.

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Amygdala Stimulation Enhances Memory for Specific Events by Modulating the Hippocampus.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Amygdala Stimulation Enhances Memory for Specific Events by Modulating the Hippocampus./
Author:	Bass, David I.
Description:	157 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-01(E), Section: B.
Contained By:	Dissertation Abstracts International76-01B(E).
Subject:	Neurosciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3639900
ISBN:	9781321249149

Amygdala Stimulation Enhances Memory for Specific Events by Modulating the Hippocampus.
Bass, David I.

Amygdala Stimulation Enhances Memory for Specific Events by Modulating the Hippocampus. - 157 p.

Source: Dissertation Abstracts International, Volume: 76-01(E), Section: B.

Thesis (Ph.D.)--Emory University, 2014.

This item is not available from ProQuest Dissertations & Theses.

Prioritization of information into long-term memory is essential for survival. Emotional arousal enhances memory for these events, and this emotional enhancement of memory is mediated by the amygdala. The amygdala has projections to many regions throughout the brain, including the hippocampus, a structure that supports memory for events. The goal of the research discussed in the present dissertation is to understand how the amygdala modulates the hippocampus in the service of enhancing memory. Characterizing the interaction between these two structures is fundamental to understanding how important information is prioritized for consolidation. Furthermore, a deeper understanding of this physiological interaction will further our understanding of the pathophysiology driving affective disorders, such as post-traumatic stress disorder. To address this goal, we developed an object recognition memory task to test memory for specific events in rats and demonstrated that brief electrical stimulation to the basolateral complex of the amygdala (BLA) selectively enhanced memory in a stimulus-specific manner when memory was tested 1 day later. In a follow-up study, we demonstrated that amygdala-mediated enhancement of memory for specific events depends on the hippocampus. Finally, we obtained recordings of local field potentials and spiking activity in the hippocampus from rats that received amygdala stimulation while performing the memory task. Data analysis took advantage of the ipsilateral connectivity between the BLA and the hippocampus by contrasting ipsilateral and contralateral stimulation. The results indicate that ipsilateral BLA stimulation elicits low gamma coherence between CA3 and CA1. Stimulation did not have a substantial impact on the firing rate of pyramidal unit populations, but ipsilateral stimulation induced a strong phase preference of CA3 pyramidal spikes relative to low gamma oscillations in the local field potential of CA1. Thus, the main effect of BLA stimulation on hippocampal pyramidal units was via modulation of spike timing. Correlations between improved memory and intra-hippocampal synchronization have previously been reported, but this is study is unique in that gamma synchronization was induced to enhance memory.

ISBN: 9781321249149Subjects--Topical Terms:

588700
Neurosciences.

Amygdala Stimulation Enhances Memory for Specific Events by Modulating the Hippocampus.
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245 1 0 $a Amygdala Stimulation Enhances Memory for Specific Events by Modulating the Hippocampus.
300 $a 157 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-01(E), Section: B.
500 $a Adviser: Joseph Manns.
502 $a Thesis (Ph.D.)--Emory University, 2014.
506 $a This item is not available from ProQuest Dissertations & Theses.
520 $a Prioritization of information into long-term memory is essential for survival. Emotional arousal enhances memory for these events, and this emotional enhancement of memory is mediated by the amygdala. The amygdala has projections to many regions throughout the brain, including the hippocampus, a structure that supports memory for events. The goal of the research discussed in the present dissertation is to understand how the amygdala modulates the hippocampus in the service of enhancing memory. Characterizing the interaction between these two structures is fundamental to understanding how important information is prioritized for consolidation. Furthermore, a deeper understanding of this physiological interaction will further our understanding of the pathophysiology driving affective disorders, such as post-traumatic stress disorder. To address this goal, we developed an object recognition memory task to test memory for specific events in rats and demonstrated that brief electrical stimulation to the basolateral complex of the amygdala (BLA) selectively enhanced memory in a stimulus-specific manner when memory was tested 1 day later. In a follow-up study, we demonstrated that amygdala-mediated enhancement of memory for specific events depends on the hippocampus. Finally, we obtained recordings of local field potentials and spiking activity in the hippocampus from rats that received amygdala stimulation while performing the memory task. Data analysis took advantage of the ipsilateral connectivity between the BLA and the hippocampus by contrasting ipsilateral and contralateral stimulation. The results indicate that ipsilateral BLA stimulation elicits low gamma coherence between CA3 and CA1. Stimulation did not have a substantial impact on the firing rate of pyramidal unit populations, but ipsilateral stimulation induced a strong phase preference of CA3 pyramidal spikes relative to low gamma oscillations in the local field potential of CA1. Thus, the main effect of BLA stimulation on hippocampal pyramidal units was via modulation of spike timing. Correlations between improved memory and intra-hippocampal synchronization have previously been reported, but this is study is unique in that gamma synchronization was induced to enhance memory.
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