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Investigation of the deregulation of...

Street, Marlene Grace A.

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Investigation of the deregulation of interleukin-6 in two non-Hodgkin's lymphoma cell lines.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Investigation of the deregulation of interleukin-6 in two non-Hodgkin's lymphoma cell lines./
作者:	Street, Marlene Grace A.
面頁冊數:	161 p.
附註:	Source: Dissertation Abstracts International, Volume: 57-02, Section: B, page: 1001.
Contained By:	Dissertation Abstracts International57-02B.
標題:	Pathology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=9617063

Investigation of the deregulation of interleukin-6 in two non-Hodgkin's lymphoma cell lines.
Street, Marlene Grace A.

Investigation of the deregulation of interleukin-6 in two non-Hodgkin's lymphoma cell lines. - 161 p.

Source: Dissertation Abstracts International, Volume: 57-02, Section: B, page: 1001.

Thesis (Ph.D.)--The University of Texas Graduate School of Biomedical Sciences at Houston, 1995.

Increased serum interleukin-6 (IL-6) is a poor prognostic factor for patients with lymphoma. This may be related to the fact that IL-6 has been shown to be an autocrine and paracrine growth factor for lymphoma cells. We have investigated the regulation of IL-6 in two lymphoma cell lines which produce IL-6 as an autocrine growth factor. The cell lines, LY3 and LY12, were established from two patients with non-Hodgkin's lymphoma. One patient had diffuse large cell lymphoma (LY3), whereas the other had small noncleaved cell lymphoma (LY12). There was no rearrangement or amplification of the IL-6 gene, but we detected IL-1 alpha and TNF production in addition to IL-6. We investigated the effect of inhibitors of IL-1 and TNF on IL-6 production in LY3 and LY12. Our results show that IL-6 production is mainly secondary to endogenous IL-1 production in LY3 cells, however LY12 cells produce IL-6 via a different mechanism since neither anti-IL-1 nor anti-TNF significantly inhibited IL-6 production.Subjects--Topical Terms:

643180
Pathology.

Investigation of the deregulation of interleukin-6 in two non-Hodgkin's lymphoma cell lines.
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100 1 $a Street, Marlene Grace A. $3 3191561
245 1 0 $a Investigation of the deregulation of interleukin-6 in two non-Hodgkin's lymphoma cell lines.
300 $a 161 p.
500 $a Source: Dissertation Abstracts International, Volume: 57-02, Section: B, page: 1001.
500 $a Supervisor: Razelle Kurzrock.
502 $a Thesis (Ph.D.)--The University of Texas Graduate School of Biomedical Sciences at Houston, 1995.
520 $a Increased serum interleukin-6 (IL-6) is a poor prognostic factor for patients with lymphoma. This may be related to the fact that IL-6 has been shown to be an autocrine and paracrine growth factor for lymphoma cells. We have investigated the regulation of IL-6 in two lymphoma cell lines which produce IL-6 as an autocrine growth factor. The cell lines, LY3 and LY12, were established from two patients with non-Hodgkin's lymphoma. One patient had diffuse large cell lymphoma (LY3), whereas the other had small noncleaved cell lymphoma (LY12). There was no rearrangement or amplification of the IL-6 gene, but we detected IL-1 alpha and TNF production in addition to IL-6. We investigated the effect of inhibitors of IL-1 and TNF on IL-6 production in LY3 and LY12. Our results show that IL-6 production is mainly secondary to endogenous IL-1 production in LY3 cells, however LY12 cells produce IL-6 via a different mechanism since neither anti-IL-1 nor anti-TNF significantly inhibited IL-6 production.
520 $a Transfection of LY12 cells with wildtype and mutant IL-6 promoter-chloramphenicol acetyl transferase constructs, showed increased activity of a trans-acting factor that binds to the NF-kB motif. Therefore, we determined whether there were abnormalities in members of the NF-kB family of transcription factors, such as p65, p50, p52/lyt-10 or rel, which bind to kB motifs. We found increased expression of the p52/lyt-10 transcription factor and activation of the NF-kB pathway in LY12. However, expression of p50, p65 and rel was not increased in LY12 cells. Future investigations could be aimed at determining the effect of inhibitors of NF-kB on IL-6 production.
590 $a School code: 2034.
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650 4 $a Immunology. $3 611031
650 4 $a Oncology. $3 751006
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791 $a Ph.D.
792 $a 1995
793 $a English
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