東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Assessment of pulmonary perfusion us...

Bell, Laura C.

Linked to FindBook

Google Book

Amazon

博客來

Assessment of pulmonary perfusion using T1-weighted dynamic contrast enhanced MRI.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Assessment of pulmonary perfusion using T1-weighted dynamic contrast enhanced MRI./
Author:	Bell, Laura C.
Description:	128 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-08(E), Section: B.
Contained By:	Dissertation Abstracts International76-08B(E).
Subject:	Medical imaging. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3688179
ISBN:	9781321663754

Assessment of pulmonary perfusion using T1-weighted dynamic contrast enhanced MRI.
Bell, Laura C.

Assessment of pulmonary perfusion using T1-weighted dynamic contrast enhanced MRI. - 128 p.

Source: Dissertation Abstracts International, Volume: 76-08(E), Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2015.

Pulmonary perfusion is the process of arterial blood flow through the capillary system of the lungs. Pulmonary perfusion is altered in different lung diseases and during various stages of lung disease making it a potential imaging biomarker for disease diagnosis, progression, and response to therapy. Magnetic resonance imaging (MRI) has shown promise as a cross-sectional modality capable of imaging both lung function (perfusion) and structure without ionizing radiation. Dynamic contrast-enhanced MRI, also known as "first pass" or "bolus tracking" is commonly implemented to qualitatively visualize perfusion; furthermore by taking advantage of the temporal behavior quantifying perfusion can be accomplished. However, several challenges exist with current scanning protocols and post-processing methods to quantify pulmonary perfusion. This research aimed to optimize the dose injection protocol, scan parameters, and post-processing steps for pulmonary perfusion. Validation of this research presented was accomplished using positron emission tomography (PET) as the clinical reference in an animal model. Additionally, lung structure is typically desired to complement perfusion for complete lung diagnosis but currently MRI protocols involve two separate scans each optimized for lung perfusion and structure. The feasibility of implementing a 3D radial acquisition for simultaneous acquisition of both lung perfusion and structure is demonstrated in an animal model as well. The purpose of this thesis was to develop tools needed to quantify pulmonary perfusion such that it could be used to monitor progressive lung diseases.

ISBN: 9781321663754Subjects--Topical Terms:

3172799
Medical imaging.

Assessment of pulmonary perfusion using T1-weighted dynamic contrast enhanced MRI.
LDR:02525nmm a2200265 4500 001 2075919
005 20161028152024.5
008 170521s2015 ||||||||||||||||| ||eng d
020 $a 9781321663754
035 $a (MiAaPQ)AAI3688179
035 $a AAI3688179
040 $a MiAaPQ $c MiAaPQ
100 1 $a Bell, Laura C. $3 3191342
245 1 0 $a Assessment of pulmonary perfusion using T1-weighted dynamic contrast enhanced MRI.
300 $a 128 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-08(E), Section: B.
500 $a Advisers: Thomas J. Grist; Scott K. Nagle.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2015.
520 $a Pulmonary perfusion is the process of arterial blood flow through the capillary system of the lungs. Pulmonary perfusion is altered in different lung diseases and during various stages of lung disease making it a potential imaging biomarker for disease diagnosis, progression, and response to therapy. Magnetic resonance imaging (MRI) has shown promise as a cross-sectional modality capable of imaging both lung function (perfusion) and structure without ionizing radiation. Dynamic contrast-enhanced MRI, also known as "first pass" or "bolus tracking" is commonly implemented to qualitatively visualize perfusion; furthermore by taking advantage of the temporal behavior quantifying perfusion can be accomplished. However, several challenges exist with current scanning protocols and post-processing methods to quantify pulmonary perfusion. This research aimed to optimize the dose injection protocol, scan parameters, and post-processing steps for pulmonary perfusion. Validation of this research presented was accomplished using positron emission tomography (PET) as the clinical reference in an animal model. Additionally, lung structure is typically desired to complement perfusion for complete lung diagnosis but currently MRI protocols involve two separate scans each optimized for lung perfusion and structure. The feasibility of implementing a 3D radial acquisition for simultaneous acquisition of both lung perfusion and structure is demonstrated in an animal model as well. The purpose of this thesis was to develop tools needed to quantify pulmonary perfusion such that it could be used to monitor progressive lung diseases.
590 $a School code: 0262.
650 4 $a Medical imaging. $3 3172799
690 $a 0574
710 2 $a The University of Wisconsin - Madison. $b Medical Physics. $3 2097834
773 0 $t Dissertation Abstracts International $g 76-08B(E).
790 $a 0262
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3688179