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Novel Approaches in Assessing Abuse ...

Zhang, Yang Maria.

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Novel Approaches in Assessing Abuse Potential of Psychotropic Medications - Pregabalin as a Test Case.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Novel Approaches in Assessing Abuse Potential of Psychotropic Medications - Pregabalin as a Test Case./
Author:	Zhang, Yang Maria.
Description:	149 p.
Notes:	Source: Masters Abstracts International, Volume: 55-04.
Contained By:	Masters Abstracts International55-04(E).
Subject:	Pharmaceutical sciences. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10044015
ISBN:	9781339554686

Novel Approaches in Assessing Abuse Potential of Psychotropic Medications - Pregabalin as a Test Case.
Zhang, Yang Maria.

Novel Approaches in Assessing Abuse Potential of Psychotropic Medications - Pregabalin as a Test Case. - 149 p.

Source: Masters Abstracts International, Volume: 55-04.

Thesis (M.Sc.)--University of Toronto (Canada), 2016.

Abuse of psychotropic medications causes significant morbidity and mortality in North America. Results from traditional assessments of abuse liability may not be generalizable to individuals with mental illnesses or for drugs with ill-defined mechanisms of action. Pregabalin is an anticonvulsant medication used off-label to manage benzodiazepine withdrawal symptoms. Simultaneously, reports of its abuse have emerged. Two novel approaches were used to assess pregabalin's abuse potential. On the macro-level, adverse drug reaction data from Canada's national database were evaluated in Study 1. Results indicated that cases found in this spontaneous reporting system can provide early indicators of prescription drug abuse. On the micro-level, Study 2 aimed to assess the acute effects of pregabalin in inpatients withdrawing from benzodiazepines and produced valuable information concerning study design, which can be used to inform future research. Overall, these novel macro-and micro-level approaches in assessing abuse potential of psychotropic drugs are complementary and synergistic with traditional methods.

ISBN: 9781339554686Subjects--Topical Terms:

3173021
Pharmaceutical sciences.

Novel Approaches in Assessing Abuse Potential of Psychotropic Medications - Pregabalin as a Test Case.
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100 1 $a Zhang, Yang Maria. $3 3190569
245 1 0 $a Novel Approaches in Assessing Abuse Potential of Psychotropic Medications - Pregabalin as a Test Case.
300 $a 149 p.
500 $a Source: Masters Abstracts International, Volume: 55-04.
500 $a Adviser: Beth A. Sproule.
502 $a Thesis (M.Sc.)--University of Toronto (Canada), 2016.
520 $a Abuse of psychotropic medications causes significant morbidity and mortality in North America. Results from traditional assessments of abuse liability may not be generalizable to individuals with mental illnesses or for drugs with ill-defined mechanisms of action. Pregabalin is an anticonvulsant medication used off-label to manage benzodiazepine withdrawal symptoms. Simultaneously, reports of its abuse have emerged. Two novel approaches were used to assess pregabalin's abuse potential. On the macro-level, adverse drug reaction data from Canada's national database were evaluated in Study 1. Results indicated that cases found in this spontaneous reporting system can provide early indicators of prescription drug abuse. On the micro-level, Study 2 aimed to assess the acute effects of pregabalin in inpatients withdrawing from benzodiazepines and produced valuable information concerning study design, which can be used to inform future research. Overall, these novel macro-and micro-level approaches in assessing abuse potential of psychotropic drugs are complementary and synergistic with traditional methods.
590 $a School code: 0779.
650 4 $a Pharmaceutical sciences. $3 3173021
650 4 $a Mental health. $3 534751
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773 0 $t Masters Abstracts International $g 55-04(E).
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856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10044015