東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Assessment of Her2-neu in Breast Can...

Aggarwal, Abha.

FindBook

Google Book

Amazon

博客來

Assessment of Her2-neu in Breast Cancer Lines Upon Differential Exposures to Xenoestrogens.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Assessment of Her2-neu in Breast Cancer Lines Upon Differential Exposures to Xenoestrogens./
作者:	Aggarwal, Abha.
面頁冊數:	255 p.
附註:	Source: Dissertation Abstracts International, Volume: 77-01(E), Section: B.
Contained By:	Dissertation Abstracts International77-01B(E).
標題:	Public health. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3723828
ISBN:	9781339068527

Assessment of Her2-neu in Breast Cancer Lines Upon Differential Exposures to Xenoestrogens.
Aggarwal, Abha.

Assessment of Her2-neu in Breast Cancer Lines Upon Differential Exposures to Xenoestrogens. - 255 p.

Source: Dissertation Abstracts International, Volume: 77-01(E), Section: B.

Thesis (Ph.D.)--Walden University, 2016.

Synthetic xenoestrogens have differential estrogenic properties. Research has shown that exposures to xenoestrogens could promote breast cancer by disrupting normal function of the human epidermal growth factor receptor 2 (Her2) gene. Although animal models demonstrated a connection between xenoestrogen exposure and Her2 activity, no study using human cells has systematically examined their carcinogenic potential influencing the Her2 gene expression. Furthermore, breast cancer cells are phenotypically disparate (ER+, Her2+), with some phenotypes (Her2+), leading to more aggressive disease. This study aimed to dosimetrically assess the carcinogenic potential of commonly used xenoestrogens influencing Her2 gene expression, and delineate cellular phenotypes at greater risk of more aggressive disease. The study assessed whether the composition, concentrations, and exposure duration of BPA, EE, NPH, and DDT significantly altered Her2 copy numbers in estrogen and Her2 receptor positive or negative breast cancer lines. Each line was randomly assigned to cases (exposed) and control (unexposed) groups using a randomized block design. Fluorescent in-situ hybridization measured Her2 gene copies. Mann Whitney, Kruskal Wallis, and Incidence Rate Ratios revealed Her2 copy gains in all 4 xenoestrogens and receptor types with persistent exposures. A 44% increase in Her2 was observed in the normal ER and Her2 line, marking a shift in its Her2 status, and a 30-times greater risk was noted in the Her2+ lines. These findings promote positive social change by revealing all 4 xenoestrogens as risk factors for breast cancer. This information can be used by breast cancer advocacy groups, health educators, and steering committees to educate women and formulating policies.

ISBN: 9781339068527Subjects--Topical Terms:

534748
Public health.

Assessment of Her2-neu in Breast Cancer Lines Upon Differential Exposures to Xenoestrogens.
LDR:02678nmm a2200289 4500 001 2074353
005 20160926125819.5
008 170521s2016 ||||||||||||||||| ||eng d
020 $a 9781339068527
035 $a (MiAaPQ)AAI3723828
035 $a AAI3723828
040 $a MiAaPQ $c MiAaPQ
100 1 $a Aggarwal, Abha. $3 3189668
245 1 0 $a Assessment of Her2-neu in Breast Cancer Lines Upon Differential Exposures to Xenoestrogens.
300 $a 255 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-01(E), Section: B.
500 $a Adviser: Amy Thompson.
502 $a Thesis (Ph.D.)--Walden University, 2016.
520 $a Synthetic xenoestrogens have differential estrogenic properties. Research has shown that exposures to xenoestrogens could promote breast cancer by disrupting normal function of the human epidermal growth factor receptor 2 (Her2) gene. Although animal models demonstrated a connection between xenoestrogen exposure and Her2 activity, no study using human cells has systematically examined their carcinogenic potential influencing the Her2 gene expression. Furthermore, breast cancer cells are phenotypically disparate (ER+, Her2+), with some phenotypes (Her2+), leading to more aggressive disease. This study aimed to dosimetrically assess the carcinogenic potential of commonly used xenoestrogens influencing Her2 gene expression, and delineate cellular phenotypes at greater risk of more aggressive disease. The study assessed whether the composition, concentrations, and exposure duration of BPA, EE, NPH, and DDT significantly altered Her2 copy numbers in estrogen and Her2 receptor positive or negative breast cancer lines. Each line was randomly assigned to cases (exposed) and control (unexposed) groups using a randomized block design. Fluorescent in-situ hybridization measured Her2 gene copies. Mann Whitney, Kruskal Wallis, and Incidence Rate Ratios revealed Her2 copy gains in all 4 xenoestrogens and receptor types with persistent exposures. A 44% increase in Her2 was observed in the normal ER and Her2 line, marking a shift in its Her2 status, and a 30-times greater risk was noted in the Her2+ lines. These findings promote positive social change by revealing all 4 xenoestrogens as risk factors for breast cancer. This information can be used by breast cancer advocacy groups, health educators, and steering committees to educate women and formulating policies.
590 $a School code: 0543.
650 4 $a Public health. $3 534748
650 4 $a Environmental health. $3 543032
650 4 $a Epidemiology. $3 568544
690 $a 0573
690 $a 0470
690 $a 0766
710 2 $a Walden University. $b Public Health. $3 1023863
773 0 $t Dissertation Abstracts International $g 77-01B(E).
790 $a 0543
791 $a Ph.D.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3723828