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Structural and functional investigat...

Yang, Chen-Yuan Charlie.

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Structural and functional investigation of the trabecular outflow pathway.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Structural and functional investigation of the trabecular outflow pathway./
Author:	Yang, Chen-Yuan Charlie.
Description:	188 p.
Notes:	Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
Contained By:	Dissertation Abstracts International77-10B(E).
Subject:	Ophthalmology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10128043
ISBN:	9781339860756

Structural and functional investigation of the trabecular outflow pathway.
Yang, Chen-Yuan Charlie.

Structural and functional investigation of the trabecular outflow pathway. - 188 p.

Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.

Thesis (Ph.D.)--Boston University, 2016.

Primary open-angle glaucoma (POAG) is a leading cause of blindness in the world. A primary risk factor for POAG is elevated intraocular pressure (IOP), caused by increased aqueous humor outflow resistance. Currently, lowering the IOP is the only effective way of treating glaucoma; however, the cause of increased outflow resistance remains unclear. This thesis will present a series of studies which investigated structures of the trabecular outflow pathway, including Schlemm's canal endothelium, juxtacanalicular tissue, and trabecular beams, and their roles in regulating aqueous outflow resistance. The studies were conducted in both human and animal models using ex vivo ocular perfusion as well as in vitro microfluidic systems. In the first study, we investigated the effects of Y27632, a derivative of Rho-kinase inhibitor that is being developed as next generation glaucoma drug with unclear IOP lowering mechanism, on aqueous humor outflow dynamics and associated morphological changes in normal human eyes and laser-induced ocular hypertensive monkey eyes. In the second study, we developed and validated a novel three-dimensional microfluidic system using lymphatic microvascular endothelial cells. The microfluidic system can be used to study Schlemm's canal endothelial cell dynamics and aqueous humor transport mechanism in the future. In the last study, we characterized the morphological structure, distribution, and thickness of the endothelial glycocalyx in the aqueous humor outflow pathway of human and bovine eyes. Together these studies will help define new directions for therapy that will help control IOP and preserve vision throughout a normal life span.

ISBN: 9781339860756Subjects--Topical Terms:

862704
Ophthalmology.

Structural and functional investigation of the trabecular outflow pathway.
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020 $a 9781339860756
035 $a (MiAaPQ)AAI10128043
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100 1 $a Yang, Chen-Yuan Charlie. $3 3189656
245 1 0 $a Structural and functional investigation of the trabecular outflow pathway.
300 $a 188 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-10(E), Section: B.
500 $a Advisers: Haiyan Gong; Roger D. Kamm.
502 $a Thesis (Ph.D.)--Boston University, 2016.
520 $a Primary open-angle glaucoma (POAG) is a leading cause of blindness in the world. A primary risk factor for POAG is elevated intraocular pressure (IOP), caused by increased aqueous humor outflow resistance. Currently, lowering the IOP is the only effective way of treating glaucoma; however, the cause of increased outflow resistance remains unclear. This thesis will present a series of studies which investigated structures of the trabecular outflow pathway, including Schlemm's canal endothelium, juxtacanalicular tissue, and trabecular beams, and their roles in regulating aqueous outflow resistance. The studies were conducted in both human and animal models using ex vivo ocular perfusion as well as in vitro microfluidic systems. In the first study, we investigated the effects of Y27632, a derivative of Rho-kinase inhibitor that is being developed as next generation glaucoma drug with unclear IOP lowering mechanism, on aqueous humor outflow dynamics and associated morphological changes in normal human eyes and laser-induced ocular hypertensive monkey eyes. In the second study, we developed and validated a novel three-dimensional microfluidic system using lymphatic microvascular endothelial cells. The microfluidic system can be used to study Schlemm's canal endothelial cell dynamics and aqueous humor transport mechanism in the future. In the last study, we characterized the morphological structure, distribution, and thickness of the endothelial glycocalyx in the aqueous humor outflow pathway of human and bovine eyes. Together these studies will help define new directions for therapy that will help control IOP and preserve vision throughout a normal life span.
590 $a School code: 0017.
650 4 $a Ophthalmology. $3 862704
650 4 $a Histology. $3 641250
650 4 $a Physiology. $3 518431
690 $a 0381
690 $a 0414
690 $a 0719
710 2 $a Boston University. $b Anatomy Neurobiology. $3 3189657
773 0 $t Dissertation Abstracts International $g 77-10B(E).
790 $a 0017
791 $a Ph.D.
792 $a 2016
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10128043