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Process systems engineering methods ...
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Rogers, Amanda J.
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Process systems engineering methods for the development of continuous pharmaceutical manufacturing processes.
紀錄類型:
書目-電子資源 : Monograph/item
正題名/作者:
Process systems engineering methods for the development of continuous pharmaceutical manufacturing processes./
作者:
Rogers, Amanda J.
面頁冊數:
185 p.
附註:
Source: Dissertation Abstracts International, Volume: 77-04(E), Section: B.
Contained By:
Dissertation Abstracts International77-04B(E).
標題:
Biochemistry. -
電子資源:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3734262
ISBN:
9781339228341
Process systems engineering methods for the development of continuous pharmaceutical manufacturing processes.
Rogers, Amanda J.
Process systems engineering methods for the development of continuous pharmaceutical manufacturing processes.
- 185 p.
Source: Dissertation Abstracts International, Volume: 77-04(E), Section: B.
Thesis (Ph.D.)--Rutgers The State University of New Jersey - New Brunswick, 2015.
The objective of this dissertation is to develop mathematical methods to assist in the development of continuous processes for the manufacture of pharmaceutical drug products. Specifically, modeling, analysis and optimization techniques will be developed in order to apply concepts from the field of process systems engineering to pharmaceutical development. These concepts, including sensitivity analysis, feasibility and flexibility analysis and optimal design under uncertainty, can contribute to the development of robust and well-understood manufacturing processes. This is consistent with the aim Quality-by-Design in the pharmaceutical process development. Throughout this dissertation, case studies related to continuous solids-based manufacturing will be used to demonstrate the role that process systems engineering can play in process development. The mathematical methods introduced in this dissertation will emphasize the use of reduced-order and surrogate models to address the unique challenges associated with modeling, analysis and optimization of solids-based processes.
ISBN: 9781339228341Subjects--Topical Terms:
518028
Biochemistry.
Process systems engineering methods for the development of continuous pharmaceutical manufacturing processes.
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