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Functional modification of chitosan ...

Tang, Ruogu.

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Functional modification of chitosan for biomedical application.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Functional modification of chitosan for biomedical application./
Author:	Tang, Ruogu.
Description:	125 p.
Notes:	Source: Masters Abstracts International, Volume: 54-04.
Contained By:	Masters Abstracts International54-04(E).
Subject:	Polymer chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1526428
ISBN:	9781321780093

Functional modification of chitosan for biomedical application.
Tang, Ruogu.

Functional modification of chitosan for biomedical application. - 125 p.

Source: Masters Abstracts International, Volume: 54-04.

Thesis (M.S.)--University of Massachusetts Lowell, 2015.

Chitosan is a linear polysaccharide. Normally commercial chitosan consists of randomly distributed beta-(1-4)-linked D-glucosamine (deacetylated proportion) and N-acetyl-D-glucosamine (acetylated proportion) together. Chitosan has been proved to be a multifunctional biopolymer that presents several unique properties due to free amino groups in the repeating unit therefore chitosan has been widely applied in various areas. To be specific, provided by the excellent biocompatibility, chitosan is expected to be used in biological and medical applications including wound dressing, implants, drug carrier/delivery, etc. In this thesis, we worked on chitosan functionalization for biomedical application. The thesis are composed of three parts:

ISBN: 9781321780093Subjects--Topical Terms:

3173488
Polymer chemistry.

Functional modification of chitosan for biomedical application.
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020 $a 9781321780093
035 $a (MiAaPQ)AAI1526428
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040 $a MiAaPQ $c MiAaPQ
100 1 $a Tang, Ruogu. $3 3184412
245 1 0 $a Functional modification of chitosan for biomedical application.
300 $a 125 p.
500 $a Source: Masters Abstracts International, Volume: 54-04.
500 $a Adviser: Yuyu Sun.
502 $a Thesis (M.S.)--University of Massachusetts Lowell, 2015.
520 $a Chitosan is a linear polysaccharide. Normally commercial chitosan consists of randomly distributed beta-(1-4)-linked D-glucosamine (deacetylated proportion) and N-acetyl-D-glucosamine (acetylated proportion) together. Chitosan has been proved to be a multifunctional biopolymer that presents several unique properties due to free amino groups in the repeating unit therefore chitosan has been widely applied in various areas. To be specific, provided by the excellent biocompatibility, chitosan is expected to be used in biological and medical applications including wound dressing, implants, drug carrier/delivery, etc. In this thesis, we worked on chitosan functionalization for biomedical application. The thesis are composed of three parts:
520 $a In the first part, we focused on modifying the chitosan thin film, chemically introducing the nitric oxide functional groups on chitosan film. We covalently bonded small molecule diazeniumdiolates onto the chitosan films and examined the antimicrobial function and biocompatibility. Commercial chitosan was cast into films from acidic aqueous solutions. Glutaraldehyde reacted with the chitosan film to introduce aldehyde groups onto the chitosan film (GA-CS film). GA-CS reacted with a small molecule NO donor, NOC-18, to covalently immobilize NONO groups onto the polymer (NO-CS film). The-CHO and [NONO] group were verified by FT IR, UV and Griess reagent. The NO releasing rate in aqueous solution and and thermal stability were studied quantitatively to prove its effectiveness. A series of antimicrobial tests indicated that NO-CS films have multiple functions: 1. It could inhibit the bacteria growth in nutrient rich environment; 2. It could directly inactivate bacteria and biofilm; 3. It could reduce the bacteria adherence on the film surface as well as inhibit biofilm formation. In addition, the NO-CS film was proved to be biocompatible with cell and it was also compatible with other antibiotics like Amoxicillin.
520 $a In the second part, we focused on chitosan treatment on titanium surface. We have covalently immobilized chitosan onto titanium (Ti), a widely used implant material, to manage implant-related infection and poor osseointegration that are two of most serious orthopedic implants. The Ti surface was first treated with sulfuric acid and then covalently reacted with chitosan. Surface properties including roughness, contact angle and zeta potential of the samples were markedly increased by the sulfuric acid treatment and the subsequent chitosan immobilization. We have cooperated with the Dr. Ying Deng group's and demonstrated that the chitosan-immobilized Ti showed two novel antimicrobial roles: It prevented the invasion and internalization of bacteria into the osteoblast-like cells; on the other hand, it significantly increased the susceptibility of adherent bacteria to antibiotics. In addition, the SA-Ti and CS-Ti led to a significantly increased osteoblast-likecell attachment, enhanced cell proliferation, and better osteogenic differentiation and mineralization of cells.
520 $a Chitosan based nanoparticle for drug loading and delivery is also reported in this thesis. By adopting the self-assembly approach, we have prepared alginate/chitosan nanoparticles where the chlorhexidine/cyclodextrin complex is loaded on. The nanoparticles have been proved to be antimicrobial effective and it can bind on cells.
590 $a School code: 0111.
650 4 $a Polymer chemistry. $3 3173488
650 4 $a Materials science. $3 543314
690 $a 0495
690 $a 0794
710 2 $a University of Massachusetts Lowell. $3 1017839
773 0 $t Masters Abstracts International $g 54-04(E).
790 $a 0111
791 $a M.S.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1526428