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Programming the Myocardium: the Notc...

Gillers, Benjamin Saul.

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Programming the Myocardium: the Notch-Wnt Axis.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Programming the Myocardium: the Notch-Wnt Axis./
Author:	Gillers, Benjamin Saul.
Description:	78 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.
Contained By:	Dissertation Abstracts International76-12B(E).
Subject:	Developmental biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3716431
ISBN:	9781321952728

Programming the Myocardium: the Notch-Wnt Axis.
Gillers, Benjamin Saul.

Programming the Myocardium: the Notch-Wnt Axis. - 78 p.

Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.

Thesis (Ph.D.)--Washington University in St. Louis, 2015.

Heart related deaths are the number one cause of death in the United States. While heart failure and other mechanical issues are common, arrhythmias account for the majority of these deaths. By understanding the genetic architecture that patterns the normal cardiac conduction system, we can further deepen our understanding of how arrhythmias arise and develop targeted therapies to treat this deadly class of disease. I have found that canonical Wnt signaling is necessary for development of the atrioventricular junction. Furthermore, absence of myocardial Wnt signaling leads to tricuspid atresia. Overexpression of Wnt signaling leads to development of ectopic atrioventricular junction tissue and induces delayed conduction velocity and other electrophysiological properties of nodal tissue. I have further found that Wnt signaling is downregulated by Notch signaling and this downregulation is required for Notch induced ventricular preexcitation. I have also developed a gene therapy platform for testing the role of these genes in cultured mouse and human cardiac tissue.

ISBN: 9781321952728Subjects--Topical Terms:

592588
Developmental biology.

Programming the Myocardium: the Notch-Wnt Axis.
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100 1 $a Gillers, Benjamin Saul. $3 3184356
245 1 0 $a Programming the Myocardium: the Notch-Wnt Axis.
300 $a 78 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-12(E), Section: B.
500 $a Adviser: Stacey Rentschler.
502 $a Thesis (Ph.D.)--Washington University in St. Louis, 2015.
520 $a Heart related deaths are the number one cause of death in the United States. While heart failure and other mechanical issues are common, arrhythmias account for the majority of these deaths. By understanding the genetic architecture that patterns the normal cardiac conduction system, we can further deepen our understanding of how arrhythmias arise and develop targeted therapies to treat this deadly class of disease. I have found that canonical Wnt signaling is necessary for development of the atrioventricular junction. Furthermore, absence of myocardial Wnt signaling leads to tricuspid atresia. Overexpression of Wnt signaling leads to development of ectopic atrioventricular junction tissue and induces delayed conduction velocity and other electrophysiological properties of nodal tissue. I have further found that Wnt signaling is downregulated by Notch signaling and this downregulation is required for Notch induced ventricular preexcitation. I have also developed a gene therapy platform for testing the role of these genes in cultured mouse and human cardiac tissue.
590 $a School code: 0252.
650 4 $a Developmental biology. $3 592588
650 4 $a Genetics. $3 530508
650 4 $a Cellular biology. $3 3172791
690 $a 0758
690 $a 0369
690 $a 0379
710 2 $a Washington University in St. Louis. $b Biologyand Biomedical Sciences (Developmental, Regenerative, and Stem Cell Biology). $3 3184357
773 0 $t Dissertation Abstracts International $g 76-12B(E).
790 $a 0252
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3716431