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Differential sensitivity of Baxdelta...

Chen, Wenjing.

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Differential sensitivity of Baxdelta2 positive and negative cells to anti-tumor agent bortezomib in colon cancer.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Differential sensitivity of Baxdelta2 positive and negative cells to anti-tumor agent bortezomib in colon cancer./
Author:	Chen, Wenjing.
Description:	38 p.
Notes:	Source: Masters Abstracts International, Volume: 54-06.
Contained By:	Masters Abstracts International54-06(E).
Subject:	Biology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1595295
ISBN:	9781321939477

Differential sensitivity of Baxdelta2 positive and negative cells to anti-tumor agent bortezomib in colon cancer.
Chen, Wenjing.

Differential sensitivity of Baxdelta2 positive and negative cells to anti-tumor agent bortezomib in colon cancer. - 38 p.

Source: Masters Abstracts International, Volume: 54-06.

Thesis (M.S.)--Illinois Institute of Technology, 2015.

Tumor suppressor Baxdelta2 is a functional Bax isoform that is found in microsatellite unstable (MSI) colon cancer. However, Baxdelta2 proteins are not stable and are prone to be degraded by proteasomes in tumor cells. Bortezomib, a proteasome inhibitor, is an FDA approved anti-cancer drug mainly used for the treatment of myeloma and lymphoma. We tested if Bortezomib can block Baxdelta2 degradation and potentially be beneficial for the treatment of Baxdelta2 positive colon cancer. In this project, we compared the efficacy of Bortezomib-induced cell death in Baxdelta2-positive and Baxdelta2-negative colon cancer cells. We found that Baxdelta2-positive cells were highly sensitive to Bortezomib-induced cell death in comparison with that in Baxdelta2-negative cells. The half maximal inhibitory concentration (IC50) of cell viability for Baxdelta2-positive cells is 11.1 nM, while it is 453.8 nM for Baxdelta2-negative cells. The results indicate that Bortezomib has a selectivity towards Baxdelta2-expressive cells and could be a drug candidate for the treatment of Baxdelta2-positive colon cancer.

ISBN: 9781321939477Subjects--Topical Terms:

522710
Biology.

Differential sensitivity of Baxdelta2 positive and negative cells to anti-tumor agent bortezomib in colon cancer.
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020 $a 9781321939477
035 $a (MiAaPQ)AAI1595295
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100 1 $a Chen, Wenjing. $3 3182905
245 1 0 $a Differential sensitivity of Baxdelta2 positive and negative cells to anti-tumor agent bortezomib in colon cancer.
300 $a 38 p.
500 $a Source: Masters Abstracts International, Volume: 54-06.
500 $a Adviser: Jialing Xiang.
502 $a Thesis (M.S.)--Illinois Institute of Technology, 2015.
520 $a Tumor suppressor Baxdelta2 is a functional Bax isoform that is found in microsatellite unstable (MSI) colon cancer. However, Baxdelta2 proteins are not stable and are prone to be degraded by proteasomes in tumor cells. Bortezomib, a proteasome inhibitor, is an FDA approved anti-cancer drug mainly used for the treatment of myeloma and lymphoma. We tested if Bortezomib can block Baxdelta2 degradation and potentially be beneficial for the treatment of Baxdelta2 positive colon cancer. In this project, we compared the efficacy of Bortezomib-induced cell death in Baxdelta2-positive and Baxdelta2-negative colon cancer cells. We found that Baxdelta2-positive cells were highly sensitive to Bortezomib-induced cell death in comparison with that in Baxdelta2-negative cells. The half maximal inhibitory concentration (IC50) of cell viability for Baxdelta2-positive cells is 11.1 nM, while it is 453.8 nM for Baxdelta2-negative cells. The results indicate that Bortezomib has a selectivity towards Baxdelta2-expressive cells and could be a drug candidate for the treatment of Baxdelta2-positive colon cancer.
590 $a School code: 0091.
650 4 $a Biology. $3 522710
650 4 $a Molecular biology. $3 517296
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690 $a 0307
710 2 $a Illinois Institute of Technology. $b Biological and Chemical Sciences. $3 3182906
773 0 $t Masters Abstracts International $g 54-06(E).
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793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1595295