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Synthesis of diverse BODIPY dyes and...

Abeywardana, Sewwandi.

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Synthesis of diverse BODIPY dyes and water solubilization strategies.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthesis of diverse BODIPY dyes and water solubilization strategies./
Author:	Abeywardana, Sewwandi.
Description:	128 p.
Notes:	Source: Masters Abstracts International, Volume: 55-02.
Contained By:	Masters Abstracts International55-02(E).
Subject:	Organic chemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1600577
ISBN:	9781339096261

Synthesis of diverse BODIPY dyes and water solubilization strategies.
Abeywardana, Sewwandi.

Synthesis of diverse BODIPY dyes and water solubilization strategies. - 128 p.

Source: Masters Abstracts International, Volume: 55-02.

Thesis (M.S.)--California State University, Long Beach, 2015.

We report the synthesis and properties of a variety of substituted 4,4-difluoro-4-bora-3a,4a-diaza- s-indacene (BODIPY), with potential to be developed into biological probes. The substituents at 2, 6-positions on the BODIPY were changed by the use of corresponding pyrrole building blocks. Electron-donating and withdrawing substituents were introduced on to the BODIPY core in order to study their effects on the photochemical properties. Different strategies were carried out to saponify the ester groups on the BODIPY to obtain the carboxylic acid derivatives. These carboxylic acid groups were expected to increase the water-solubility of the BODIPY as well as facilitate the bio-conjugation. However, due to incompatibility of the BODIPY core to the reaction conditions, targeted products were not obtained. In couple of cases, the meso position was functionalized by 4-formylbenzoic acid to enable the bio-conjugation of new dyes. Alternative routes to synthesize carboxylic acid derivatives of the novel BODIPYs are under investigation.

ISBN: 9781339096261Subjects--Topical Terms:

523952
Organic chemistry.

Synthesis of diverse BODIPY dyes and water solubilization strategies.
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008 170521s2015 ||||||||||||||||| ||eng d
020 $a 9781339096261
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100 1 $a Abeywardana, Sewwandi. $3 3182509
245 1 0 $a Synthesis of diverse BODIPY dyes and water solubilization strategies.
300 $a 128 p.
500 $a Source: Masters Abstracts International, Volume: 55-02.
500 $a Adviser: Michael P. Schramm.
502 $a Thesis (M.S.)--California State University, Long Beach, 2015.
520 $a We report the synthesis and properties of a variety of substituted 4,4-difluoro-4-bora-3a,4a-diaza- s-indacene (BODIPY), with potential to be developed into biological probes. The substituents at 2, 6-positions on the BODIPY were changed by the use of corresponding pyrrole building blocks. Electron-donating and withdrawing substituents were introduced on to the BODIPY core in order to study their effects on the photochemical properties. Different strategies were carried out to saponify the ester groups on the BODIPY to obtain the carboxylic acid derivatives. These carboxylic acid groups were expected to increase the water-solubility of the BODIPY as well as facilitate the bio-conjugation. However, due to incompatibility of the BODIPY core to the reaction conditions, targeted products were not obtained. In couple of cases, the meso position was functionalized by 4-formylbenzoic acid to enable the bio-conjugation of new dyes. Alternative routes to synthesize carboxylic acid derivatives of the novel BODIPYs are under investigation.
590 $a School code: 6080.
650 4 $a Organic chemistry. $3 523952
690 $a 0490
710 2 $a California State University, Long Beach. $b Chemistry and Biochemistry. $3 3181224
773 0 $t Masters Abstracts International $g 55-02(E).
790 $a 6080
791 $a M.S.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1600577