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Arsenic toxicity and altered mitocho...

Mickey, Kristen Elizabeth.

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Arsenic toxicity and altered mitochondrial bioenergetics in response to oxidative stress.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Arsenic toxicity and altered mitochondrial bioenergetics in response to oxidative stress./
作者:	Mickey, Kristen Elizabeth.
面頁冊數:	64 p.
附註:	Source: Masters Abstracts International, Volume: 54-05.
Contained By:	Masters Abstracts International54-05(E).
標題:	Toxicology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1591109
ISBN:	9781321816174

Arsenic toxicity and altered mitochondrial bioenergetics in response to oxidative stress.
Mickey, Kristen Elizabeth.

Arsenic toxicity and altered mitochondrial bioenergetics in response to oxidative stress. - 64 p.

Source: Masters Abstracts International, Volume: 54-05.

Thesis (M.S.)--University of Kansas, 2015.

Environmental exposure to arsenic is a worldwide health concern which is linked to a number of diseases. Areas with arsenic levels above the current safe concentration have higher levels of skin, lung, liver, and bladder cancers and non-carcinogenic pathologies, including neuropathy, cardiovascular diseases and diabetes mellitus. Understanding the mechanism by which arsenic exerts its toxic effects is crucial to developing preventative strategies and more effective treatments for individuals with long term exposure to arsenic compounds.

ISBN: 9781321816174Subjects--Topical Terms:

556884
Toxicology.

Arsenic toxicity and altered mitochondrial bioenergetics in response to oxidative stress.
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245 1 0 $a Arsenic toxicity and altered mitochondrial bioenergetics in response to oxidative stress.
300 $a 64 p.
500 $a Source: Masters Abstracts International, Volume: 54-05.
500 $a Adviser: Partha Kasturi.
502 $a Thesis (M.S.)--University of Kansas, 2015.
520 $a Environmental exposure to arsenic is a worldwide health concern which is linked to a number of diseases. Areas with arsenic levels above the current safe concentration have higher levels of skin, lung, liver, and bladder cancers and non-carcinogenic pathologies, including neuropathy, cardiovascular diseases and diabetes mellitus. Understanding the mechanism by which arsenic exerts its toxic effects is crucial to developing preventative strategies and more effective treatments for individuals with long term exposure to arsenic compounds.
520 $a This thesis outlines the epidemiological evidence for arsenic-linked diseases as well as the current understanding of arsenic metabolism and the mechanism(s) of how arsenic exerts its cytotoxicity.
520 $a The liver is a major site of arsenic uptake and biotransformation and thus is affected by high arsenic levels. Generation of reactive oxygen species (ROS) has been shown to play a major role in the toxic effects of arsenic. Using primary and immortalized hepatocyte cell lines these studies investigate how arsenic generates the production of ROS. The localization of superoxide was shown to overlap with mitochondria and antioxidant enzymes were shown to be induced after arsenic treatment. Measurement of mitochondria function through oxygen consumption rate (OCR) shows that arsenic affects oxidative phosphorylation and the ability for mitochondria to efficiently couple electron transport with ATP production. Understanding the source of ROS from arsenic exposure and how cells cope with altered mitochondrial bioenergetics is an important building block for future studies on arsenic toxicity and for developing treatments for arsenic exposure.
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650 4 $a Cellular biology. $3 3172791
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710 2 $a University of Kansas. $b Pharmacology, Toxicology and Therapeutics. $3 3181565
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