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Resting-State fMRI Study of Pediatri...

Patriat, Remi.

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Resting-State fMRI Study of Pediatric Post-Traumatic Stress Disorder: Preprocessing Optimization and Clinical Observations.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Resting-State fMRI Study of Pediatric Post-Traumatic Stress Disorder: Preprocessing Optimization and Clinical Observations./
作者:	Patriat, Remi.
面頁冊數:	253 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.
Contained By:	Dissertation Abstracts International76-09B(E).
標題:	Medical imaging. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3700339
ISBN:	9781321702446

Resting-State fMRI Study of Pediatric Post-Traumatic Stress Disorder: Preprocessing Optimization and Clinical Observations.
Patriat, Remi.

Resting-State fMRI Study of Pediatric Post-Traumatic Stress Disorder: Preprocessing Optimization and Clinical Observations. - 253 p.

Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2015.

This item must not be sold to any third party vendors.

Resting-state functional magnetic resonance imaging (rs-fMRI) is a reliable technique to map the functional organization of the brain particularly useful for a clinical setting as it does not rely on task performance, contrary to task fMRI. Rs-fMRI can shed light on the underlying neuronal differences between pPTSD patients and healthy controls. This modality, however, suffers from many artifacts arising from in-scanner motion and the patient's physiology (breathing and heart rate changes). Another drawback is a lack of standardization in the pre-processing and the processing of the data. Finding the optimum pre-processing pipeline is key to obtaining the best and the most consistent results that will lead to a better understanding of the brain.

ISBN: 9781321702446Subjects--Topical Terms:

3172799
Medical imaging.

Resting-State fMRI Study of Pediatric Post-Traumatic Stress Disorder: Preprocessing Optimization and Clinical Observations.
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245 1 0 $a Resting-State fMRI Study of Pediatric Post-Traumatic Stress Disorder: Preprocessing Optimization and Clinical Observations.
300 $a 253 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-09(E), Section: B.
500 $a Adviser: Rasmus M. Birn.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2015.
506 $a This item must not be sold to any third party vendors.
520 $a Resting-state functional magnetic resonance imaging (rs-fMRI) is a reliable technique to map the functional organization of the brain particularly useful for a clinical setting as it does not rely on task performance, contrary to task fMRI. Rs-fMRI can shed light on the underlying neuronal differences between pPTSD patients and healthy controls. This modality, however, suffers from many artifacts arising from in-scanner motion and the patient's physiology (breathing and heart rate changes). Another drawback is a lack of standardization in the pre-processing and the processing of the data. Finding the optimum pre-processing pipeline is key to obtaining the best and the most consistent results that will lead to a better understanding of the brain.
520 $a One interesting patient population to study is pediatric post-traumatic stress disorder (pPTSD), which is a mental illness that currently has relatively few treatment options. Behavioral therapy shows modest effect sizes, while no medication has been proven to treat PTSD in youth. Developing new therapies requires a better understanding of the underlying neural substrates of pediatric PTSD. Using rs-fMRI to study pPTSD is both novel and challenging. It is novel because, to date, there have been no reports of rs-fMRI in pPTSD, and it is challenging because pediatric populations are more difficult to study due to a higher amount of motion.
520 $a The goals of this study are: 1/ Assessing the test-retest reliability of rs-fMRI 2/ Creating motion correction methods and the best possible pipeline to obtain the best connectivity estimates 3/ Estimating functional connectivity differences between pPTSD patients and healthy controls 4/ Studying the influence of different behavioral measures on pPTSD connectivity patterns..
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