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Roles of epithelial-mesenchymal tran...

Uthaya Kumar, Dinesh Babu.

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Roles of epithelial-mesenchymal transition and niche in tumorigenesis of tumor-initiating cells.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Roles of epithelial-mesenchymal transition and niche in tumorigenesis of tumor-initiating cells./
作者:	Uthaya Kumar, Dinesh Babu.
面頁冊數:	68 p.
附註:	Source: Masters Abstracts International, Volume: 54-01.
Contained By:	Masters Abstracts International54-01(E).
標題:	Pathology. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1568207
ISBN:	9781321305012

Roles of epithelial-mesenchymal transition and niche in tumorigenesis of tumor-initiating cells.
Uthaya Kumar, Dinesh Babu.

Roles of epithelial-mesenchymal transition and niche in tumorigenesis of tumor-initiating cells. - 68 p.

Source: Masters Abstracts International, Volume: 54-01.

Thesis (M.S.)--University of Southern California, 2014.

This item is not available from ProQuest Dissertations & Theses.

BACKGROUND & AIMS: Alcohol and obesity cause steatohepatitis through activation of Toll-like receptor-4 (TLR4) signaling and enhance hepatitis C virus (HCV) associated liver carcinogenesis. The HCV NS5A protein ectopoically upregulates TLR4 in hepatocytes, generates TLR4/NANOG dependent liver tumor initiating stem cell-like cells (TICs), and induces liver tumor in alcohol fed transgenic (Tg) mice. These TICs have robust and selective expression of the leptin receptor, and increased phosphorylation and activation of STAT3. However, whether the TLR4-NANOG pathway promotes an oncogenic signaling in other etiological mouse models and patients is ambiguous. METHOD: We sought to determine whether a Western diet high in cholesterol, and saturated fat (HCFD) that causes obesity can also synergistically induce liver tumors via TLR4 signaling. RESULTS: We have identified the TLR4- NANOG oncogenic pathway in the genesis of TICs, and liver tumor in alcohol and/or HCFD fed NS5A Tg mice. An sensitized response in TICs to LPS and/or Leptin resulted in an enchanced Twist1 Promoter activity, which was abrogated by silencing: Tlr4, Nanog or Stat3. We provide evidence of NANOG and STAT3 sharing their binding site on Twist1 promoter to transactive it. CONCLUSION: Taken together, TLR4-NANOG axis promotes liver tumorigenesis/metastasis through accentuated mesenchymal phenotype with elevated Twist1 expression upon exposure to HCV and alcohol/high-fat diets. The TLR4 pathway serves as a novel therapeutic target for HCC.

ISBN: 9781321305012Subjects--Topical Terms:

643180
Pathology.

Roles of epithelial-mesenchymal transition and niche in tumorigenesis of tumor-initiating cells.
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