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Fabrication and Biological Evaluatio...

Petrochenko, Peter Evgeniyevich.

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Fabrication and Biological Evaluation of Micro- and Nanostructured Surfaces, Coatings, and 3D-printed Scaffolds to Improve Function and Biocompatibility of Medical Devices.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Fabrication and Biological Evaluation of Micro- and Nanostructured Surfaces, Coatings, and 3D-printed Scaffolds to Improve Function and Biocompatibility of Medical Devices./
作者:	Petrochenko, Peter Evgeniyevich.
面頁冊數:	362 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.
Contained By:	Dissertation Abstracts International76-11B(E).
標題:	Biomedical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3710673
ISBN:	9781321866568

Fabrication and Biological Evaluation of Micro- and Nanostructured Surfaces, Coatings, and 3D-printed Scaffolds to Improve Function and Biocompatibility of Medical Devices.
Petrochenko, Peter Evgeniyevich.

Fabrication and Biological Evaluation of Micro- and Nanostructured Surfaces, Coatings, and 3D-printed Scaffolds to Improve Function and Biocompatibility of Medical Devices. - 362 p.

Source: Dissertation Abstracts International, Volume: 76-11(E), Section: B.

Thesis (Ph.D.)--North Carolina State University, 2015.

There is a considerable gap in nanotoxicological research on nanofeatured surfaces. The current understanding of nanomaterials and their toxicity is largely based from studies using discreet nanoparticle systems, which do not translate to surface mediated toxicity but are nevertheless useful for understanding the means of nanomaterials toxicity. Cytotoxicity in a discrete rare earth engineered nanoparticle model was investigated; internalization of nanoparticles by cells, supernatant toxicity, as well as the role of endotoxin in nanoparticle formulations was reported and discussed. Aside from nanoparticles, however, numerous current and proposed immobilized nanomaterials are of benefit to the medical device industry. Nanomaterials can be coated, etched or formed directly into the surface of a medical device, improving its antimicrobial activity, biocompatibility, material properties and much more. Several methods for reliable coating of immobilized nanomaterials were investigated in detail and a 3D printing method using two photon polymerization for creating free standing constructs was reported. Pulsed laser deposition was shown to have the capability of fabricating uniform controllable antimicrobial zinc oxide coatings as well as creating composite polymer/metal material coatings such as PMMA and silver. The leaching parameters from such surfaces were evaluated and toxicological in vitro exposure endpoints were drawn based on a given concentration of a toxic leachate, such as ionic zinc or silver. The amount of nanosilver coating into the PMMA composite was optimized to create a coating that was antibacterial but non-cytotoxic to human cells. Initial characterization of fabricated nanomaterials was given high importance due to the fundamental need of understanding the physical and chemical basis of both adverse and desired toxicological outcomes. A variety of nanoscale features were characterized for their unique physicochemical characteristics (controllable roughness, enhanced UV absorption, adjustable stiffness) and were examined for their contribution to a number of observed unique biological responses (increased protein adsorption, enhanced cell proliferation, antimicrobial activity, and many others). Advancements in chemical coating methods of delicate nanomaterials structures were reported in both a ceramic nanoporous alumina model as well as a polymeric polyethersulfone (PES) model. Atomic layer deposition of titanium dioxide was shown to successfully coat intricate nanoporous alumina membranes without affecting their intrinsic permeability, while drastically improving the UV-protection of PES and preventing the resulting toxicity. In the field of 3D printing, the first instance of medium throughput fabrication of custom scaffold materials with submicron texture was demonstrated. The scaffold constructs were 3D printed from a custom designed elastomer that matched both the stiffness and the nanotexture experienced by cells in the bodily environment. The improvements in nanoscale fabrication of device surface coatings, chemical surface modification, and submicron 3D printing described in this thesis have advanced the current understanding of parameters that affect toxicity, biocompatibility, and long term success of medical devices incorporating nanotechnology.

ISBN: 9781321866568Subjects--Topical Terms:

535387
Biomedical engineering.

Fabrication and Biological Evaluation of Micro- and Nanostructured Surfaces, Coatings, and 3D-printed Scaffolds to Improve Function and Biocompatibility of Medical Devices.
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