東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

Non-Contrast Enhanced Cardiovascular...

Kali, Avinash.

FindBook

Google Book

Amazon

博客來

Non-Contrast Enhanced Cardiovascular Magnetic Resonance Imaging for Characterizing Chronic Myocardial Infarctions.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Non-Contrast Enhanced Cardiovascular Magnetic Resonance Imaging for Characterizing Chronic Myocardial Infarctions./
作者:	Kali, Avinash.
面頁冊數:	352 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-10(E), Section: B.
Contained By:	Dissertation Abstracts International76-10B(E).
標題:	Biomedical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3706054
ISBN:	9781321794960

Non-Contrast Enhanced Cardiovascular Magnetic Resonance Imaging for Characterizing Chronic Myocardial Infarctions.
Kali, Avinash.

Non-Contrast Enhanced Cardiovascular Magnetic Resonance Imaging for Characterizing Chronic Myocardial Infarctions. - 352 p.

Source: Dissertation Abstracts International, Volume: 76-10(E), Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2015.

Myocardial infarction (MI) is the leading cause of morbidity and death globally. Non-invasive characterization of chronic MIs is of significant clinical importance due to its association with adverse cardiac outcomes such as cardiac arrhythmias, heart failure, and sudden cardiac death. Late Gadolinium Enhancement (LGE) MRI has evolved into a robust non-invasive imaging technique for characterizing chronic MIs and identifying new pathophysiological substrates of adverse cardiac outcomes within chronic MIs. However, the requisite Gadolinium administration in LGE MRI is contra-indicated in nearly 25% of the MI patients due to co-morbidity of chronic kidney disease. In this light, there has been a growing interest to develop non-contrast enhanced MRI techniques for robust characterization of chronic MIs.

ISBN: 9781321794960Subjects--Topical Terms:

535387
Biomedical engineering.

Non-Contrast Enhanced Cardiovascular Magnetic Resonance Imaging for Characterizing Chronic Myocardial Infarctions.
LDR:03129nmm a2200301 4500 001 2064294
005 20151109142632.5
008 170521s2015 ||||||||||||||||| ||eng d
020 $a 9781321794960
035 $a (MiAaPQ)AAI3706054
035 $a AAI3706054
040 $a MiAaPQ $c MiAaPQ
100 1 $a Kali, Avinash. $3 3178861
245 1 0 $a Non-Contrast Enhanced Cardiovascular Magnetic Resonance Imaging for Characterizing Chronic Myocardial Infarctions.
300 $a 352 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-10(E), Section: B.
500 $a Advisers: Rohan Dharmakumar; Daniel B. Ennis.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2015.
520 $a Myocardial infarction (MI) is the leading cause of morbidity and death globally. Non-invasive characterization of chronic MIs is of significant clinical importance due to its association with adverse cardiac outcomes such as cardiac arrhythmias, heart failure, and sudden cardiac death. Late Gadolinium Enhancement (LGE) MRI has evolved into a robust non-invasive imaging technique for characterizing chronic MIs and identifying new pathophysiological substrates of adverse cardiac outcomes within chronic MIs. However, the requisite Gadolinium administration in LGE MRI is contra-indicated in nearly 25% of the MI patients due to co-morbidity of chronic kidney disease. In this light, there has been a growing interest to develop non-contrast enhanced MRI techniques for robust characterization of chronic MIs.
520 $a This dissertation focuses on the development of novel non-Gadolinium based MRI techniques for robust characterization of chronic MIs and pathological substrates of adverse cardiac outcomes. Using extensive histopathology in an animal model and validation studies in chronic MI patients, native T1 mapping at 3T was shown to characterize chronic MIs with high diagnostic accuracy. The second part of the dissertation focuses on detecting post-reperfusion intramyocardial hemorrhage using non-contrast enhanced MRI techniques, and its role as a potential pathological substrate of adverse cardiac outcomes in chronic MIs. Using histopathology and mass spectrometry analysis, T2* MRI was shown to be a highly sensitive technique for detecting hemorrhage and its degradation byproducts. Hemorrhage was found to persist within chronic MIs for several months post-MI in the form of localized iron deposits, which in turn was found to be associated with prolonged inflammatory burden and adverse left-ventricular remodeling. Using high-resolution electroanatomical maps co-registered with T2*-weighted images, localized iron deposition within chronic MIs was found to be a potential arrhythmogenic substrate. The prognostic value of cardiac T2* MRI for risk-stratifying patients susceptible to malignant ventricular arrhythmias was evaluated.
590 $a School code: 0031.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Medical imaging. $3 3172799
650 4 $a Physiology. $3 518431
690 $a 0541
690 $a 0574
690 $a 0719
710 2 $a University of California, Los Angeles. $b Biomedical Engineering. $3 3178845
773 0 $t Dissertation Abstracts International $g 76-10B(E).
790 $a 0031
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3706054