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Bioengineering of Tendons using Cont...

Biedrzycki, Adam Henry.

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Bioengineering of Tendons using Controlled Spatiotemporal Release of Multiple Growth Factors and Concurrent Monitoring of Healing via Elasticity Mapping Ultrasonography.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Bioengineering of Tendons using Controlled Spatiotemporal Release of Multiple Growth Factors and Concurrent Monitoring of Healing via Elasticity Mapping Ultrasonography./
作者:	Biedrzycki, Adam Henry.
面頁冊數:	311 p.
附註:	Source: Dissertation Abstracts International, Volume: 76-06(E), Section: B.
Contained By:	Dissertation Abstracts International76-06B(E).
標題:	Biomedical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3680337
ISBN:	9781321523096

Bioengineering of Tendons using Controlled Spatiotemporal Release of Multiple Growth Factors and Concurrent Monitoring of Healing via Elasticity Mapping Ultrasonography.
Biedrzycki, Adam Henry.

Bioengineering of Tendons using Controlled Spatiotemporal Release of Multiple Growth Factors and Concurrent Monitoring of Healing via Elasticity Mapping Ultrasonography. - 311 p.

Source: Dissertation Abstracts International, Volume: 76-06(E), Section: B.

Thesis (Ph.D.)--The University of Wisconsin - Madison, 2015.

Clinically effective treatments for tendon lacerations are equivocal and current protocols are associated with high levels of morbidity and re-injury. Injured tendons have limited self-healing capacity, due in part to poor vascularity and low metabolite supply. Furthermore, tendon-healing assessments are currently based on grey-scale echogenicity and appearance of organized tendon fibrils or scar tissue.

ISBN: 9781321523096Subjects--Topical Terms:

535387
Biomedical engineering.

Bioengineering of Tendons using Controlled Spatiotemporal Release of Multiple Growth Factors and Concurrent Monitoring of Healing via Elasticity Mapping Ultrasonography.
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245 1 0 $a Bioengineering of Tendons using Controlled Spatiotemporal Release of Multiple Growth Factors and Concurrent Monitoring of Healing via Elasticity Mapping Ultrasonography.
300 $a 311 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-06(E), Section: B.
500 $a Adviser: Mark D. Markel.
502 $a Thesis (Ph.D.)--The University of Wisconsin - Madison, 2015.
520 $a Clinically effective treatments for tendon lacerations are equivocal and current protocols are associated with high levels of morbidity and re-injury. Injured tendons have limited self-healing capacity, due in part to poor vascularity and low metabolite supply. Furthermore, tendon-healing assessments are currently based on grey-scale echogenicity and appearance of organized tendon fibrils or scar tissue.
520 $a The aims of this research were to accelerate gain in mechanical strength and histological organization of tendon tissue after a partial tenotomy in a rabbit model, via the use of two growth factors (fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF)) released from suture material in a spatiotemporal fashion to coincide with the phases of tendon healing. In addition, we evaluated the effect of growth factor use on tendon vascularity via both histological assessment and microbubble contrast angiography (MCA). We also evaluated novel methods of monitoring tendon healing via the use of acoustoelastography (AE) and shear wave imaging (SWI).
520 $a The studies presented in this thesis demonstrate that FGF and VEGF were able to synergistically enhance the healing of tendon tissue using our suture material delivery platform. The use of our optimal suture group resulted in supra-physiological tensile strengths at a 4-week post surgical evaluation time point. This thesis provides evidence that in addition to superior mechanical properties, superior histological organization was also attained. Superior healing was achieved with the addition of the angiogenic compounds and this angiogenic effect was identified successfully using MCA and histological evaluation techniques.
520 $a The use of AE and SWI was also correlated to structural and material properties of tendon, respectively, and these imaging modalities provided enhanced information in regard to the healing of the tendon tissue non-invasively.
520 $a In our 9-week post surgical long-term evaluation, we identified that the supra-physiological tensile strength values attained at the 4-week short term with our optimal growth factor group returned to baseline normal physiological values. The 9-week optimal growth factor group also demonstrated superior histological organization and a reduction in tendon cross sectional area. Thus, this thesis suggests that tendon healing mechanisms may mirror the remodeling process that occurs in bone. Further work is warranted, to provide supplementary evidence to support the idea of coupled remodeling in tendon tissue.
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