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A study of the effects of oxidation ...

Washington, Joseph Benjamin, III.

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A study of the effects of oxidation and glycation on the cyclic loading response of isolated arterial elastin.

Record Type:	Electronic resources : Monograph/item
Title/Author:	A study of the effects of oxidation and glycation on the cyclic loading response of isolated arterial elastin./
Author:	Washington, Joseph Benjamin, III.
Description:	224 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-10(E), Section: B.
Contained By:	Dissertation Abstracts International76-10B(E).
Subject:	Engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3707336
ISBN:	9781321818383

A study of the effects of oxidation and glycation on the cyclic loading response of isolated arterial elastin.
Washington, Joseph Benjamin, III.

A study of the effects of oxidation and glycation on the cyclic loading response of isolated arterial elastin. - 224 p.

Source: Dissertation Abstracts International, Volume: 76-10(E), Section: B.

Thesis (Ph.D.)--University of Maryland, Baltimore County, 2015.

This item must not be sold to any third party vendors.

Elastin is a stable and resilient protein that undergoes large deformations under low force. In the arterial tree, elastin allows the arterial wall to expand and recover as high-pressured blood is pumped from the heart. In addition, elastin stores elastic-strain energy, allowing arteries to smooth the pulsatile flow of blood from the heart, lowering peak BP, and the mechanical work of the heart. As a material, elastin is extremely durable, capable of undergoing over a billion cycles under normal hemostatic conditions, and because of its resiliency, is an attractive scaffolding material for tissue engineering applications. Aging of elastic tissue may be attributed to changes in the cross-linking of the polypeptide chain caused by biochemical processes such as oxidation and glycation, and mechanical fatigue. Little research has been done to understand the effects of biochemical changes through oxidation and glycation on the cyclic loading response of arterial elastin. Fatigue testing of materials has shown that mechanical properties such as modulus, residual and ultimate strength change with increasing number of cycles.

ISBN: 9781321818383Subjects--Topical Terms:

586835
Engineering.

A study of the effects of oxidation and glycation on the cyclic loading response of isolated arterial elastin.
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008 170521s2015 ||||||||||||||||| ||eng d
020 $a 9781321818383
035 $a (MiAaPQ)AAI3707336
035 $a AAI3707336
040 $a MiAaPQ $c MiAaPQ
100 1 $a Washington, Joseph Benjamin, III. $3 3178470
245 1 2 $a A study of the effects of oxidation and glycation on the cyclic loading response of isolated arterial elastin.
300 $a 224 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-10(E), Section: B.
500 $a Adviser: Tim Topoleski.
502 $a Thesis (Ph.D.)--University of Maryland, Baltimore County, 2015.
506 $a This item must not be sold to any third party vendors.
520 $a Elastin is a stable and resilient protein that undergoes large deformations under low force. In the arterial tree, elastin allows the arterial wall to expand and recover as high-pressured blood is pumped from the heart. In addition, elastin stores elastic-strain energy, allowing arteries to smooth the pulsatile flow of blood from the heart, lowering peak BP, and the mechanical work of the heart. As a material, elastin is extremely durable, capable of undergoing over a billion cycles under normal hemostatic conditions, and because of its resiliency, is an attractive scaffolding material for tissue engineering applications. Aging of elastic tissue may be attributed to changes in the cross-linking of the polypeptide chain caused by biochemical processes such as oxidation and glycation, and mechanical fatigue. Little research has been done to understand the effects of biochemical changes through oxidation and glycation on the cyclic loading response of arterial elastin. Fatigue testing of materials has shown that mechanical properties such as modulus, residual and ultimate strength change with increasing number of cycles.
520 $a The work presented in this research examines the effects of glycation and oxidation on the structural and cyclic loading response of isolated arterial elastin. Two models, a linear and a Neo-Hookean model, were employed to evaluate the change in the mechanical response of arteries due to chemical glycation, oxidation and cyclic loading. While the linear model provided a better fit to our data, both models identified significant differences between treatment groups and number of cycles. In addition, this study investigated a damage model that could quantitatively detect changes in the cyclic loading response that could be attributed to fatigue damage. Although the models used in this study were able to detect changes due to cyclic loading and oxidation treatment, more work needs to be done to develop better models for the study of the cyclic loading response of isolated arterial elastin.
590 $a School code: 0434.
650 4 $a Engineering. $3 586835
650 4 $a Biomechanics. $3 548685
690 $a 0537
690 $a 0648
710 2 $a University of Maryland, Baltimore County. $b Mechanical Engineering. $3 3178471
773 0 $t Dissertation Abstracts International $g 76-10B(E).
790 $a 0434
791 $a Ph.D.
792 $a 2015
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3707336