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Physical Properties of Mesoporous Si...

Dong, Juyao.

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Physical Properties of Mesoporous Silica Nanoparticles for Stimuli-Responsive Drug Delivery.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Physical Properties of Mesoporous Silica Nanoparticles for Stimuli-Responsive Drug Delivery./
Author:	Dong, Juyao.
Description:	230 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-04(E), Section: B.
Contained By:	Dissertation Abstracts International76-04B(E).
Subject:	Biochemistry. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3667096
ISBN:	9781321409857

Physical Properties of Mesoporous Silica Nanoparticles for Stimuli-Responsive Drug Delivery.
Dong, Juyao.

Physical Properties of Mesoporous Silica Nanoparticles for Stimuli-Responsive Drug Delivery. - 230 p.

Source: Dissertation Abstracts International, Volume: 76-04(E), Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2014.

This item is not available from ProQuest Dissertations & Theses.

The on-demand drug release of mesoporous silica nanoparticles is investigated by chemical modifications of nanomachines and by spectroscopic examination of their physical properties. To improve and diversify their biological performances, acid responsive nanovalve release systems are integrated with gadolinium MRI contrast agents and polyethylene imine-polyethylene glycol surface coatings. Nanoparticles, and bulk media for comparison, are heated superparamagnetically and their temperatures are monitored using the luminescence spectra of lanthanide upconversion nanocrystals. This thermometry technique is applied again in azobenzene nanoimpeller particles to analyze the photothermal and photochemical contributions of IR radiation in initiating cargo release. The emission spectra prove capable of revealing the nanoscale temperature change and the macroscopic dye release simultaneously. Mesoporous silica nanoparticles demonstrate versatile nanomedical delivery capabilities in vitro and in vivo..

ISBN: 9781321409857Subjects--Topical Terms:

518028
Biochemistry.

Physical Properties of Mesoporous Silica Nanoparticles for Stimuli-Responsive Drug Delivery.
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500 $a Source: Dissertation Abstracts International, Volume: 76-04(E), Section: B.
500 $a Adviser: Jeffrey I. Zink.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2014.
506 $a This item is not available from ProQuest Dissertations & Theses.
506 $a This item must not be sold to any third party vendors.
520 $a The on-demand drug release of mesoporous silica nanoparticles is investigated by chemical modifications of nanomachines and by spectroscopic examination of their physical properties. To improve and diversify their biological performances, acid responsive nanovalve release systems are integrated with gadolinium MRI contrast agents and polyethylene imine-polyethylene glycol surface coatings. Nanoparticles, and bulk media for comparison, are heated superparamagnetically and their temperatures are monitored using the luminescence spectra of lanthanide upconversion nanocrystals. This thermometry technique is applied again in azobenzene nanoimpeller particles to analyze the photothermal and photochemical contributions of IR radiation in initiating cargo release. The emission spectra prove capable of revealing the nanoscale temperature change and the macroscopic dye release simultaneously. Mesoporous silica nanoparticles demonstrate versatile nanomedical delivery capabilities in vitro and in vivo..
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650 4 $a Nanoscience. $3 587832
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