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Skeletal and tissue response to auto...

Tricomi, Brad John Scott.

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Skeletal and tissue response to automated, continuous, curvilinear distraction osteogenesis: A clinical and histological study.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Skeletal and tissue response to automated, continuous, curvilinear distraction osteogenesis: A clinical and histological study./
作者:	Tricomi, Brad John Scott.
面頁冊數:	121 p.
附註:	Source: Masters Abstracts International, Volume: 53-01.
Contained By:	Masters Abstracts International53-01(E).
標題:	Biomedical engineering. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1557049
ISBN:	9781303938290

Skeletal and tissue response to automated, continuous, curvilinear distraction osteogenesis: A clinical and histological study.
Tricomi, Brad John Scott.

Skeletal and tissue response to automated, continuous, curvilinear distraction osteogenesis: A clinical and histological study. - 121 p.

Source: Masters Abstracts International, Volume: 53-01.

Thesis (M.S.)--University of Massachusetts Boston, 2014.

This item must not be sold to any third party vendors.

PURPOSE: To evaluate bone and soft tissue healing at rates faster than 1 mm/day following automated, continuous, curvilinear distraction osteogenesis in a minipig model.

ISBN: 9781303938290Subjects--Topical Terms:

535387
Biomedical engineering.

Skeletal and tissue response to automated, continuous, curvilinear distraction osteogenesis: A clinical and histological study.
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100 1 $a Tricomi, Brad John Scott. $3 3178321
245 1 0 $a Skeletal and tissue response to automated, continuous, curvilinear distraction osteogenesis: A clinical and histological study.
300 $a 121 p.
500 $a Source: Masters Abstracts International, Volume: 53-01.
500 $a Adviser: Maria J. Troulis.
502 $a Thesis (M.S.)--University of Massachusetts Boston, 2014.
506 $a This item must not be sold to any third party vendors.
520 $a PURPOSE: To evaluate bone and soft tissue healing at rates faster than 1 mm/day following automated, continuous, curvilinear distraction osteogenesis in a minipig model.
520 $a MATERIALS AND METHODS: 10 Yucatan minipigs in the mixed-dentition stage underwent automated, continuous, curvilinear DO of the right mandible. Animals were distracted 12 mm at rates of 1.5 (n=5) and 3.0 mm/day (n=5) followed by 24 days of fixation. The animals were sacrificed and bone and soft tissue healing was evaluated. A semi-quantitative scale was used to assess the ex vivo clinical appearance of the distraction gap (3=osteotomy not visible; 2=50% visible; 0=100% visible), stability (3=no mobility; 2 and 1=mobility in 1 plane or 2 planes, respectively; 0=mobility in 3 planes), and radiographic density (4=100% of gap opaque; 3=>75%; 2=50% to 75%; 1=<50%; 0 = radiolucent). Animals distracted discontinuously (rhythm=2x/day) at 1, 2, and 4 mm/day were used as the controls (n=4-6). The distracted and contralateral mandibular bodies were harvested at the end of the fixation period. The percent surface area (PSA) of the distraction wound occupied by bone, fibrous tissue, cartilage and hematoma were determined by computerized histomorphometric analysis. Control groups consisted of DO wounds distracted discontinuously at 1 mm/day (n=2) and the non-operated contralateral mandible (n=3). The experimental and control side digastric muscles were harvested and stained for proliferating-cell-nuclear-antigen (PCNA), myogenic-differentiation-1 (MyoD), and paired-Box-7-protein (PAX7).
520 $a RESULTS: Automated, continuous DO at 1.5 mm/day and 3.0 mm/day had similar bone formation compared to the discontinuous, 1 mm/day positive control. Continuous DO at 1.5 mm/day had significantly increased scores for appearance and radiographic density than the discontinuous 4 mm/day group. The continuous DO 3 mm/day group had significantly greater appearance and radiographic density scores compared with the discontinuous 4 mm/day groups and higher stability compared to the discontinuous 2 and 4 mm/day groups. PSA occupied by bone for the continuous 1.5, 3.0, and discontinuous DO at 1 mm/day were similar (1.5 mm/day PSA=64.36+/-5.87, 3.0 mm/day PSA=63.83+/-3.37, and 1.0 mm/day PSA=64.89+/-0.56), but less than the nonoperated side (PSA=84.67+/-0.86). PSA occupied by cartilage and hematoma in all groups was minimal (< 1.1%). The digastric muscles had no abnormal tissue or inflammation and PAX7, MyoD, and PCNA expression had returned to baseline levels.
520 $a CONCLUSIONS: Results of this study indicate that bone fill of the continuous distraction wound at rates of 1.5 and 3 mm/day was similar to that of discontinuous DO at 1 mm/day. Continuous DO at rates of 1.5 and 3.0 mm/day allows nearly identical PSA occupied by bone when compared to discontinuous DO at 1 mm/day. Digastric muscles exhibited no deleterious effects caused by DO. This supports the potential to shorten treatment time for management of craniofacial deformities.
590 $a School code: 1074.
650 4 $a Biomedical engineering. $3 535387
650 4 $a Morphology. $3 591167
650 4 $a Surgery. $3 707153
690 $a 0541
690 $a 0287
690 $a 0576
710 2 $a University of Massachusetts Boston. $b Biology (MS). $3 3178322
773 0 $t Masters Abstracts International $g 53-01(E).
790 $a 1074
791 $a M.S.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1557049