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Different Patterns of Cortical Alter...

Feng, Yuwei.

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Different Patterns of Cortical Alterations in Autism with and without Comorbid Intellectual Disability.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Different Patterns of Cortical Alterations in Autism with and without Comorbid Intellectual Disability./
作者:	Feng, Yuwei.
面頁冊數:	20 p.
附註:	Source: Masters Abstracts International, Volume: 54-05.
Contained By:	Masters Abstracts International54-05(E).
標題:	Neurosciences. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=1590821
ISBN:	9781321806069

Different Patterns of Cortical Alterations in Autism with and without Comorbid Intellectual Disability.
Feng, Yuwei.

Different Patterns of Cortical Alterations in Autism with and without Comorbid Intellectual Disability. - 20 p.

Source: Masters Abstracts International, Volume: 54-05.

Thesis (M.S.)--University of California, Davis, 2015.

This item must not be sold to any third party vendors.

Autism spectrum disorder (ASD) is a heterogeneous condition, with varying behavioral presentations and comorbidities. An estimated 30% of children diagnosed with ASD have comorbid intellectual disability (ID). Little is known, however, about how the neuroanatomical profiles differ between ASD with and without comorbid ID. We utilized multivariate pattern analyses (MVPA) to compare regional cortical gray matter volumes in three groups: (1) ASD and comorbid ID (ASD+ID), (2) ASD without ID (ASD-ID), and (3) age-matched typical developing (TD) controls. Structural MRIs were acquired in 83 boys (27 ASD+ID, 28 ASD-ID, 28 TD) with a mean age of 36.2 months. Cortical gray matter was parcellated into 34 gyral regions per hemisphere using Freesurfer (v5.1.0). Cognitive testing was carried out at two time points, study entry and two years later (mean 65.9 months). Only participants with stable IQ scores were included. We utilized cross-validated linear Support vector machine (SVM), controlling for total cerebral volume (TCV), to classify ASD+ID vs TD, ASD-ID vs TD, and ASD+ID vs ASD, left and right hemispheres separately. Result includes: performance (accuracy, sensitivity, specificity), and regions' weights that contributed to each classification. Classification accuracies were mostly significant for all three comparisons. ASD+ID vs TD on both hemispheres had the highest two accuracies. ASD-ID vs TD performed more accurate on left than right hemisphere. Significant overlap in regions existed among patterns, particularly frontal and temporal lobes. ASD with and without comorbid ID have overlapping, but different neural phenotypes. Children with ASD+ID have a more diffuse pattern of alterations. A better characterization of unique patterns of brain alterations in different subgroups of ASD may lead to more specific, targeted intervention strategies.

ISBN: 9781321806069Subjects--Topical Terms:

588700
Neurosciences.

Different Patterns of Cortical Alterations in Autism with and without Comorbid Intellectual Disability.
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