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Linoleic acid and leukocyte inflamma...

Raphael, William.

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Linoleic acid and leukocyte inflammatory markers in periparturient dairy cows.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Linoleic acid and leukocyte inflammatory markers in periparturient dairy cows./
Author:	Raphael, William.
Description:	129 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.
Contained By:	Dissertation Abstracts International75-08B(E).
Subject:	Veterinary science. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3617807
ISBN:	9781303856150

Linoleic acid and leukocyte inflammatory markers in periparturient dairy cows.
Raphael, William.

Linoleic acid and leukocyte inflammatory markers in periparturient dairy cows. - 129 p.

Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.

Thesis (Ph.D.)--Michigan State University, 2014.

This item must not be sold to any third party vendors.

Incidence and severity of dairy cow disease is greatest in the periparturient period. Mobilization of saturated and unsaturated fatty acids from adipose tissue into plasma is a well-established risk factor for periparturient disease. Lipid mobilization was associated with changes in peripheral leukocyte content of polyunsaturated fatty acids and could impact production of the mediators of inflammatory pathways known as oxylipids. Previous bovine leukocyte studies associated expression of some proinflammatory markers and enhanced inflammatory responses to endotoxin with increased disease incidence and severity during the periparturient period. However, the potential impact of oxylipids on leukocyte inflammatory marker expression during the periparturient period is unknown. The hypothesis of the Chapter 2 study was that a relationship exists between the profile of pro- and anti-inflammatory plasma oxylipids and the inflammatory phenotype of peripheral blood leukocytes during the periparturient period. Correlations were identified between concentrations of several plasma oxylipids, including some derived from linoleic acid, and expression of some proinflammatory markers by peripheral blood leukocytes. Previous reports of increased linoleic acid concentrations within mononuclear leukocytes during early lactation were confirmed. Human studies showed proinflammatory effects of linoleic acid in several cell types through oxylipid production. Early lactation monocytes were modeled in vitro to evaluate effects of increased linoleic acid concentrations on oxylipid production and inflammatory marker expression. The overall hypothesis of Chapter 3 studies was that increased monocyte linoleic acid concentrations enhance production of linoleic acid-derived oxylipids, induce a pro-inflammatory phenotype, and enhance inflammatory responses to endotoxin. Results showed increased production of several linoleic acid-derived oxylipids in primary bovine and murine RAW 264.7 monocytes with linoleic acid concentrations similar to early lactation cows. Increasing linoleic acid concentrations in monocytes did not impact pro- or anti-inflammatory marker expression and did not influence endotoxin-stimulated inflammatory responses. Future studies should evaluate the impact of individual oxylipids, produced by monocytes in response to increased linoleic acid concentration, on inflammatory marker expression.

ISBN: 9781303856150Subjects--Topical Terms:

3172798
Veterinary science.

Linoleic acid and leukocyte inflammatory markers in periparturient dairy cows.
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020 $a 9781303856150
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100 1 $a Raphael, William. $3 3174933
245 1 0 $a Linoleic acid and leukocyte inflammatory markers in periparturient dairy cows.
300 $a 129 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-08(E), Section: B.
500 $a Adviser: Lorraine M. Sordillo.
502 $a Thesis (Ph.D.)--Michigan State University, 2014.
506 $a This item must not be sold to any third party vendors.
520 $a Incidence and severity of dairy cow disease is greatest in the periparturient period. Mobilization of saturated and unsaturated fatty acids from adipose tissue into plasma is a well-established risk factor for periparturient disease. Lipid mobilization was associated with changes in peripheral leukocyte content of polyunsaturated fatty acids and could impact production of the mediators of inflammatory pathways known as oxylipids. Previous bovine leukocyte studies associated expression of some proinflammatory markers and enhanced inflammatory responses to endotoxin with increased disease incidence and severity during the periparturient period. However, the potential impact of oxylipids on leukocyte inflammatory marker expression during the periparturient period is unknown. The hypothesis of the Chapter 2 study was that a relationship exists between the profile of pro- and anti-inflammatory plasma oxylipids and the inflammatory phenotype of peripheral blood leukocytes during the periparturient period. Correlations were identified between concentrations of several plasma oxylipids, including some derived from linoleic acid, and expression of some proinflammatory markers by peripheral blood leukocytes. Previous reports of increased linoleic acid concentrations within mononuclear leukocytes during early lactation were confirmed. Human studies showed proinflammatory effects of linoleic acid in several cell types through oxylipid production. Early lactation monocytes were modeled in vitro to evaluate effects of increased linoleic acid concentrations on oxylipid production and inflammatory marker expression. The overall hypothesis of Chapter 3 studies was that increased monocyte linoleic acid concentrations enhance production of linoleic acid-derived oxylipids, induce a pro-inflammatory phenotype, and enhance inflammatory responses to endotoxin. Results showed increased production of several linoleic acid-derived oxylipids in primary bovine and murine RAW 264.7 monocytes with linoleic acid concentrations similar to early lactation cows. Increasing linoleic acid concentrations in monocytes did not impact pro- or anti-inflammatory marker expression and did not influence endotoxin-stimulated inflammatory responses. Future studies should evaluate the impact of individual oxylipids, produced by monocytes in response to increased linoleic acid concentration, on inflammatory marker expression.
590 $a School code: 0128.
650 4 $a Veterinary science. $3 3172798
650 4 $a Animal sciences. $3 3174829
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710 2 $a Michigan State University. $b Comparative Medicine and Integrative Biology - Doctor of Philosophy. $3 2093084
773 0 $t Dissertation Abstracts International $g 75-08B(E).
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791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3617807