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Magnetic resonance image-based hydro...

Shaffer, Nicholas M.

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Magnetic resonance image-based hydrodynamic analysis of cerebrospinal fluid motion in Type I Chiari malformation.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Magnetic resonance image-based hydrodynamic analysis of cerebrospinal fluid motion in Type I Chiari malformation./
Author:	Shaffer, Nicholas M.
Description:	197 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-06(E), Section: B.
Contained By:	Dissertation Abstracts International76-06B(E).
Subject:	Mechanical engineering. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3680502
ISBN:	9781321525113

Magnetic resonance image-based hydrodynamic analysis of cerebrospinal fluid motion in Type I Chiari malformation.
Shaffer, Nicholas M.

Magnetic resonance image-based hydrodynamic analysis of cerebrospinal fluid motion in Type I Chiari malformation. - 197 p.

Source: Dissertation Abstracts International, Volume: 76-06(E), Section: B.

Thesis (Ph.D.)--The University of Akron, 2014.

This item must not be sold to any third party vendors.

Type I Chiari malformation (CMI) is a complex disorder of the craniospinal system that is estimated to effect as many as 1:1000 adults in the US. In CMI, the fluid space near the craniovertebral junction becomes compressed and the tonsils of the cerebellum become stretched downward through the foramen magnum (FM), creating a partial blockage to the motion of cerebrospinal fluid (CSF) in the subarachnoid spaces. Diagnosis of the disorder is difficult because the most commonly used diagnostic criterion, cerebellar tonsil descent (CTD) >3-5 mm past the foramen magnum does not correlate well with patient symptom severity.

ISBN: 9781321525113Subjects--Topical Terms:

649730
Mechanical engineering.

Magnetic resonance image-based hydrodynamic analysis of cerebrospinal fluid motion in Type I Chiari malformation.
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100 1 $a Shaffer, Nicholas M. $3 3174125
245 1 0 $a Magnetic resonance image-based hydrodynamic analysis of cerebrospinal fluid motion in Type I Chiari malformation.
300 $a 197 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-06(E), Section: B.
500 $a Adviser: Francis Loth.
502 $a Thesis (Ph.D.)--The University of Akron, 2014.
506 $a This item must not be sold to any third party vendors.
506 $a This item must not be added to any third party search indexes.
520 $a Type I Chiari malformation (CMI) is a complex disorder of the craniospinal system that is estimated to effect as many as 1:1000 adults in the US. In CMI, the fluid space near the craniovertebral junction becomes compressed and the tonsils of the cerebellum become stretched downward through the foramen magnum (FM), creating a partial blockage to the motion of cerebrospinal fluid (CSF) in the subarachnoid spaces. Diagnosis of the disorder is difficult because the most commonly used diagnostic criterion, cerebellar tonsil descent (CTD) >3-5 mm past the foramen magnum does not correlate well with patient symptom severity.
520 $a Because of the hydrodynamic component of the disorder, subject-specific computational modeling of cerebrospinal fluid dynamics may have utility in identifying biomechanical parameters to (1) quantify the severity of CMI and (2) quantify the changes to the CMI-affected spinal canal created by corrective surgery. In the first study presented in this work, magnetic resonance image based computational models of the cervical spinal canal were used of CSF dynamics showed that longitudinal impedance (LI) to CSF motion was elevated in a group of CMI patients compared to healthy volunteers and did not correlate well with CTD.
520 $a In the second study, a similar modeling methodology was used to compare pre-surgery CMI patients, post-surgery CMI patients, and healthy volunteers. LI was compared against CTD, cross-sectional area, hydraulic diameter, gradients at peak systole, peak diastole, and peakto- peak pressure gradient. LI was found to decrease significantly post-surgery on average, but remained significantly higher than in healthy volunteers. LI was found to be sensitive to small average changes in the cross-sectional geometry of the SSS, but only correlated weakly with 14 changes to CTD. However, because of the preponderance of female patients in the study, presurgery and post-surgery LI data may have been biased low.
520 $a Finally, velocity fields at the foramen magnum and C2 level of the spinal canal were compared to validate the subject-specific models against physical measurements from 2D phasecontrast MRI. Peak velocities and through-plane velocity profiles compared poorly between CFD and 2D pcMRI. CFD showed a trend of underestimating the peak velocities observed in 2D pcMRI at both the FM and C2 levels of the spinal canal. CFD velocity profiles at C2 lacked the anterior flow dominance and heterogeneous velocity distributions typically seen in 2D pcMRI measurements. Thus, CFD velocity fields could not be validated using 2D pcMRI.
590 $a School code: 0003.
650 4 $a Mechanical engineering. $3 649730
650 4 $a Biomedical engineering. $3 535387
650 4 $a Pathology. $3 643180
650 4 $a Medical imaging. $3 3172799
690 $a 0548
690 $a 0541
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710 2 $a The University of Akron. $b Mechanical Engineering. $3 2094131
773 0 $t Dissertation Abstracts International $g 76-06B(E).
790 $a 0003
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3680502