東華大學圖書館 |

Language: English

Help

回圖書館首頁

手機版館藏查詢

Back

Switch To: Labeled | MARC Mode | ISBD

Towards image-guided pediatric atria...

Mefleh, Fuad Nedal.

Linked to FindBook

Google Book

Amazon

博客來

Towards image-guided pediatric atrial septal defect repair.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Towards image-guided pediatric atrial septal defect repair./
Author:	Mefleh, Fuad Nedal.
Description:	105 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-02(E), Section: B.
Contained By:	Dissertation Abstracts International76-02B(E).
Subject:	Medical imaging. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3636837
ISBN:	9781321187472

Towards image-guided pediatric atrial septal defect repair.
Mefleh, Fuad Nedal.

Towards image-guided pediatric atrial septal defect repair. - 105 p.

Source: Dissertation Abstracts International, Volume: 76-02(E), Section: B.

Thesis (Ph.D.)--Clemson University, 2014.

This item must not be sold to any third party vendors.

Congenital heart disease occurs in 107.6 out of 10,000 live births, with Atrial Septal Defects (ASD) accounting for 10\% of these conditions. Historically, ASDs were treated with open heart surgery using cardiopulmonary bypass, allowing a patch to be sewn over the defect. In 1976, King et al. demonstrated use of a transcatheter occlusion procedure, thus reducing the invasiveness of ASD repair. Localization during these catheter based procedures traditionally has relied on bi-plane fluoroscopy; more recently trans-esophageal echocardiography (TEE) and intra-cardiac echocardiography (ICE) have been used to navigate these procedures. Although there is a high success rate using the transcatheter occlusion procedure, fluoroscopy poses radiation dose risk to both patient and clinician. The impact of this dose to the patients is important as many of those undergoing this procedure are children, who have an increased risk associated with radiation exposure. Their longer life expectancy than adults provides a larger window of opportunity for expressing the damaging effects of ionizing radiation. In addition, epidemiologic studies of exposed populations have demonstrated that children are considerably more sensitive to the carcinogenic effects radiation.

ISBN: 9781321187472Subjects--Topical Terms:

3172799
Medical imaging.

Towards image-guided pediatric atrial septal defect repair.
LDR:04634nmm a2200337 4500 001 2059967
005 20150822105425.5
008 170521s2014 ||||||||||||||||| ||eng d
020 $a 9781321187472
035 $a (MiAaPQ)AAI3636837
035 $a AAI3636837
040 $a MiAaPQ $c MiAaPQ
100 1 $a Mefleh, Fuad Nedal. $3 3174103
245 1 0 $a Towards image-guided pediatric atrial septal defect repair.
300 $a 105 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-02(E), Section: B.
500 $a Adviser: David M. Kwartowitz.
502 $a Thesis (Ph.D.)--Clemson University, 2014.
506 $a This item must not be sold to any third party vendors.
520 $a Congenital heart disease occurs in 107.6 out of 10,000 live births, with Atrial Septal Defects (ASD) accounting for 10\% of these conditions. Historically, ASDs were treated with open heart surgery using cardiopulmonary bypass, allowing a patch to be sewn over the defect. In 1976, King et al. demonstrated use of a transcatheter occlusion procedure, thus reducing the invasiveness of ASD repair. Localization during these catheter based procedures traditionally has relied on bi-plane fluoroscopy; more recently trans-esophageal echocardiography (TEE) and intra-cardiac echocardiography (ICE) have been used to navigate these procedures. Although there is a high success rate using the transcatheter occlusion procedure, fluoroscopy poses radiation dose risk to both patient and clinician. The impact of this dose to the patients is important as many of those undergoing this procedure are children, who have an increased risk associated with radiation exposure. Their longer life expectancy than adults provides a larger window of opportunity for expressing the damaging effects of ionizing radiation. In addition, epidemiologic studies of exposed populations have demonstrated that children are considerably more sensitive to the carcinogenic effects radiation.
520 $a Image-guided surgery (IGS) uses pre-operative and intra-operative images to guide surgery or an interventional procedure. Central to every IGS system is a software application capable of processing and displaying patient images, registration between multiple coordinate systems, and interfacing with a tool tracking system. We have developed a novel image-guided surgery framework called Kit for Navigation by Image Focused Exploration (KNIFE). This software system serves as the core technology by which a system for reduction of radiation exposure to pediatric patients was developed. The bulk of the initial work in this research endevaour was the development of KNIFE which itself went through countless iterations before arriving at its current state as per the feature requirements established.
520 $a Secondly, since this work involved the use of captured medical images and their use in an IGS software suite, a brief analysis of the physics behind the images was conducted. Through this aspect of the work, intrinsic parameters (principal point and focal point) of the fluoroscope were quantified using a 3D grid calibration phantom. A second grid phantom was traversed through the fluoroscopic imaging volume of II and flat panel based systems at 2 cm intervals building a scatter field of the volume to demonstrate pincushion and "S" distortion in the images. Effects of projection distortion on the images was assessed by measuring the fiducial registration error (FRE) of each point used in two different registration techniques, where both methods utilized ordinary procrustes analysis but the second used a projection matrix built from the fluoroscopes calculated intrinsic parameters. A case study was performed to test whether the projection registration outperforms the rigid transform only.
520 $a Using the knowledge generated were able to successfully design and complete mock clinical procedures using cardiac phantom models. These mock trials at the beginning of this work used a single point to represent catheter location but this was eventually replaced with a full shape model that offered numerous advantages. At the conclusion of this work a novel protocol for conducting IG ASD procedures was developed. Future work would involve the construction of novel EM tracked tools, phantom models for other vascular diseases and finally clinical integration and use.
590 $a School code: 0050.
650 4 $a Medical imaging. $3 3172799
650 4 $a Surgery. $3 707153
650 4 $a Biomedical engineering. $3 535387
690 $a 0574
690 $a 0576
690 $a 0541
710 2 $a Clemson University. $b Bioengineering. $3 1058001
773 0 $t Dissertation Abstracts International $g 76-02B(E).
790 $a 0050
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3636837