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Chromatographic Analysis and Separat...
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Biba, Mirlinda.
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Chromatographic Analysis and Separation of Short RNA Oligonucleotides with Novel Liquid Chromatography Methods.
Record Type:
Electronic resources : Monograph/item
Title/Author:
Chromatographic Analysis and Separation of Short RNA Oligonucleotides with Novel Liquid Chromatography Methods./
Author:
Biba, Mirlinda.
Description:
187 p.
Notes:
Source: Dissertation Abstracts International, Volume: 75-11(E), Section: B.
Contained By:
Dissertation Abstracts International75-11B(E).
Subject:
Analytical chemistry. -
Online resource:
http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3629086
ISBN:
9781321057492
Chromatographic Analysis and Separation of Short RNA Oligonucleotides with Novel Liquid Chromatography Methods.
Biba, Mirlinda.
Chromatographic Analysis and Separation of Short RNA Oligonucleotides with Novel Liquid Chromatography Methods.
- 187 p.
Source: Dissertation Abstracts International, Volume: 75-11(E), Section: B.
Thesis (Ph.D.)--Drexel University, 2014.
This item must not be sold to any third party vendors.
Synthetic oligonucleotides have become increasingly important as part of new developments in the use of antisense and small interfering ribonucleic acid (siRNA) as potential therapies for the treatment of various different diseases. The development of analytical methods for the sensitive and quantitative analysis and separation of oligonucleotides is an essential part for the advancement of this research area. A typical oligonucleotide therapeutic sample is a short RNA-based oligonucleotide with about 21-mer length (∼7-8 kDa), and with possible chemical modifications prepared by chemical synthesis using an automated synthesizer. Due to their relatively large sizes compared to typical small-molecule compounds, oligonucleotides can be difficult to analyze with traditional analytical methods. There are many different analytical techniques reported for the analysis and separation of oligonucleotides, including capillary gel electrophoresis (CGE), anion-exchange high performance liquid chromatography (AEX-HPLC), and ion-pair reversed-phase liquid chromatography (IP-RPLC). In these research studies, existing liquid chromatography methods for the separation of oligonucleotides were evaluated for improved separations. New and novel approaches were also explored for more efficient analysis and separation of oligonucleotides.
ISBN: 9781321057492Subjects--Topical Terms:
3168300
Analytical chemistry.
Chromatographic Analysis and Separation of Short RNA Oligonucleotides with Novel Liquid Chromatography Methods.
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187 p.
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Source: Dissertation Abstracts International, Volume: 75-11(E), Section: B.
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Adviser: Joe Foley.
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Thesis (Ph.D.)--Drexel University, 2014.
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Synthetic oligonucleotides have become increasingly important as part of new developments in the use of antisense and small interfering ribonucleic acid (siRNA) as potential therapies for the treatment of various different diseases. The development of analytical methods for the sensitive and quantitative analysis and separation of oligonucleotides is an essential part for the advancement of this research area. A typical oligonucleotide therapeutic sample is a short RNA-based oligonucleotide with about 21-mer length (∼7-8 kDa), and with possible chemical modifications prepared by chemical synthesis using an automated synthesizer. Due to their relatively large sizes compared to typical small-molecule compounds, oligonucleotides can be difficult to analyze with traditional analytical methods. There are many different analytical techniques reported for the analysis and separation of oligonucleotides, including capillary gel electrophoresis (CGE), anion-exchange high performance liquid chromatography (AEX-HPLC), and ion-pair reversed-phase liquid chromatography (IP-RPLC). In these research studies, existing liquid chromatography methods for the separation of oligonucleotides were evaluated for improved separations. New and novel approaches were also explored for more efficient analysis and separation of oligonucleotides.
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http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3629086
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