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The Hidden Costs of Housing Practice...

David, John M.

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The Hidden Costs of Housing Practices: The importance of murine cold-stress to science.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The Hidden Costs of Housing Practices: The importance of murine cold-stress to science./
Author:	David, John M.
Description:	116 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-06(E), Section: B.
Contained By:	Dissertation Abstracts International75-06B(E).
Subject:	Veterinary science. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3613686
ISBN:	9781303770401

The Hidden Costs of Housing Practices: The importance of murine cold-stress to science.
David, John M.

The Hidden Costs of Housing Practices: The importance of murine cold-stress to science. - 116 p.

Source: Dissertation Abstracts International, Volume: 75-06(E), Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2014.

This item is not available from ProQuest Dissertations & Theses.

Laboratory mice housed in modern vivariums are chronically cold-stressed. Coldstressed mice exhibit compensatory non-shivering thermogenesis that drives a significant increase in total energy expenditure. In this manuscript, we will describe the visualization and quantification of non-shivering thermogenesis with thermography as a metric of murine cold-stress (Chapter 2). Utilizing thermography to measure cold-stress within the vivarium, we will show mice housed in individually ventilated caging, a popular and important housing system, exhibit significantly greater non-shivering thermogenesis than mice housed in static cages. Xenograft tumors implanted in mice housed in individually ventilated cages have blunted growth and metabolism compared to static cages. The experimental variability between housing systems can be significantly, but incompletely, mitigated by the addition of shelters that allow mice to maintain heated micro-climates (Chapter 3). Housing dependent variations in experimental results is likely a confounder throughout murine dependent research. We designed and validated novel ventilated caging designed to minimize the chilling effects of individually ventilated cages while preserving the benefits of ventilated caging (Chapter 4).

ISBN: 9781303770401Subjects--Topical Terms:

3172798
Veterinary science.

The Hidden Costs of Housing Practices: The importance of murine cold-stress to science.
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245 1 4 $a The Hidden Costs of Housing Practices: The importance of murine cold-stress to science.
300 $a 116 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-06(E), Section: B.
500 $a Advisers: David B. Stout; Arion-Xenofen Hadjioannou.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2014.
506 $a This item is not available from ProQuest Dissertations & Theses.
506 $a This item must not be sold to any third party vendors.
520 $a Laboratory mice housed in modern vivariums are chronically cold-stressed. Coldstressed mice exhibit compensatory non-shivering thermogenesis that drives a significant increase in total energy expenditure. In this manuscript, we will describe the visualization and quantification of non-shivering thermogenesis with thermography as a metric of murine cold-stress (Chapter 2). Utilizing thermography to measure cold-stress within the vivarium, we will show mice housed in individually ventilated caging, a popular and important housing system, exhibit significantly greater non-shivering thermogenesis than mice housed in static cages. Xenograft tumors implanted in mice housed in individually ventilated cages have blunted growth and metabolism compared to static cages. The experimental variability between housing systems can be significantly, but incompletely, mitigated by the addition of shelters that allow mice to maintain heated micro-climates (Chapter 3). Housing dependent variations in experimental results is likely a confounder throughout murine dependent research. We designed and validated novel ventilated caging designed to minimize the chilling effects of individually ventilated cages while preserving the benefits of ventilated caging (Chapter 4).
590 $a School code: 0031.
650 4 $a Veterinary science. $3 3172798
650 4 $a Medical imaging. $3 3172799
650 4 $a Biology. $3 522710
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710 2 $a University of California, Los Angeles. $b Molec & Med Pharmacology 0639. $3 3172797
773 0 $t Dissertation Abstracts International $g 75-06B(E).
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