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Synthesis of biomimetic phosphorus-c...

Yakovlev, Ilya.

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Synthesis of biomimetic phosphorus-containing polypeptides.

Record Type:	Electronic resources : Monograph/item
Title/Author:	Synthesis of biomimetic phosphorus-containing polypeptides./
Author:	Yakovlev, Ilya.
Description:	210 p.
Notes:	Source: Dissertation Abstracts International, Volume: 76-03(E), Section: B.
Contained By:	Dissertation Abstracts International76-03B(E).
Subject:	Chemistry, Polymer. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3642542
ISBN:	9781321295184

Synthesis of biomimetic phosphorus-containing polypeptides.
Yakovlev, Ilya.

Synthesis of biomimetic phosphorus-containing polypeptides. - 210 p.

Source: Dissertation Abstracts International, Volume: 76-03(E), Section: B.

Thesis (Ph.D.)--University of California, Los Angeles, 2014.

This item is not available from ProQuest Dissertations & Theses.

Immune response has historically been a major issue in the drug delivery field. In order to combat this problem, drug carriers have been designed to avoid the body's innate defenses. Following decades of research, it was found that an ideal drug delivery vehicle should enter the body, evade the immune system, stay in circulation long enough to seek out affected cells, and release the payload selectively. Furthermore, the vehicle should be comprised of materials that are non-toxic and biodegradable. While a number of potentially viable materials have been produced, there has arguably not been one which encompasses all these properties.

ISBN: 9781321295184Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Synthesis of biomimetic phosphorus-containing polypeptides.
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020 $a 9781321295184
035 $a (MiAaPQ)AAI3642542
035 $a AAI3642542
040 $a MiAaPQ $c MiAaPQ
100 1 $a Yakovlev, Ilya. $3 3170845
245 1 0 $a Synthesis of biomimetic phosphorus-containing polypeptides.
300 $a 210 p.
500 $a Source: Dissertation Abstracts International, Volume: 76-03(E), Section: B.
500 $a Adviser: Timothy J. Deming.
502 $a Thesis (Ph.D.)--University of California, Los Angeles, 2014.
506 $a This item is not available from ProQuest Dissertations & Theses.
506 $a This item must not be sold to any third party vendors.
520 $a Immune response has historically been a major issue in the drug delivery field. In order to combat this problem, drug carriers have been designed to avoid the body's innate defenses. Following decades of research, it was found that an ideal drug delivery vehicle should enter the body, evade the immune system, stay in circulation long enough to seek out affected cells, and release the payload selectively. Furthermore, the vehicle should be comprised of materials that are non-toxic and biodegradable. While a number of potentially viable materials have been produced, there has arguably not been one which encompasses all these properties.
520 $a Using phosphocholine-containing vesicles or micelles as drug delivery vehicles is one potential solution. Phospholipids, the major components of biological membranes, have also been explored for drug delivery purposes; however, their use has not been successful due to the low stability of phospholipid vesicles. Thus, biomimetic polymers with pendant phosphocholine groups were used to increase drug delivery vehicle stability. Much like other polymers, polypeptides may serve as a superior alternative due to the biodegradability of their backbone. Polypeptide synthesis has been thoroughly explored in the previous decades; however no reliable method for the preparation of phosphorus- and phosphatidylcholine-containing polypeptides has been published by the inception of this work.
520 $a Herein we discuss methods for preparation of phosphonate and phosphatidylcholine containing polypeptides. Synthesis of these materials builds on robust methods often employed in solution phase DNA synthesis. Protecting group strategies as well as the failures leading up to the polymers' successful synthesis are described. The polymers are synthesized via Co(PMe3)4 initiated polymerization of NCAs and are incorporated into diblock copolypeptides. The resultant products display interesting solution and calcium-binging properties.
590 $a School code: 0031.
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Engineering, Biomedical. $3 1017684
690 $a 0495
690 $a 0541
710 2 $a University of California, Los Angeles. $b Chemistry 0153. $3 2096181
773 0 $t Dissertation Abstracts International $g 76-03B(E).
790 $a 0031
791 $a Ph.D.
792 $a 2014
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3642542