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Responsive polymer-based colloids fo...

Kudina, Olena.

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Responsive polymer-based colloids for drug delivery and bioconversion.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Responsive polymer-based colloids for drug delivery and bioconversion./
作者:	Kudina, Olena.
面頁冊數:	231 p.
附註:	Source: Dissertation Abstracts International, Volume: 75-12(E), Section: B.
Contained By:	Dissertation Abstracts International75-12B(E).
標題:	Chemistry, Polymer. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3633082
ISBN:	9781321125610

Responsive polymer-based colloids for drug delivery and bioconversion.
Kudina, Olena.

Responsive polymer-based colloids for drug delivery and bioconversion. - 231 p.

Source: Dissertation Abstracts International, Volume: 75-12(E), Section: B.

Thesis (Ph.D.)--North Dakota State University, 2014.

This item must not be sold to any third party vendors.

Responsive polymer-based colloids (RPBC) are the colloidal structures containing responsive polymeric component which is able to adapt its physico-chemical properties to the environment by undergoing chemical and/or conformational changes.

ISBN: 9781321125610Subjects--Topical Terms:

1018428
Chemistry, Polymer.

Responsive polymer-based colloids for drug delivery and bioconversion.
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100 1 $a Kudina, Olena. $3 3170829
245 1 0 $a Responsive polymer-based colloids for drug delivery and bioconversion.
300 $a 231 p.
500 $a Source: Dissertation Abstracts International, Volume: 75-12(E), Section: B.
500 $a Adviser: Andriy Voronov.
502 $a Thesis (Ph.D.)--North Dakota State University, 2014.
506 $a This item must not be sold to any third party vendors.
520 $a Responsive polymer-based colloids (RPBC) are the colloidal structures containing responsive polymeric component which is able to adapt its physico-chemical properties to the environment by undergoing chemical and/or conformational changes.
520 $a The goal of the dissertation is to develop and characterize several groups of RPBC with different morphological complexity and explore their potential in drug delivery and bioconversion. The role of RPBC morphology for these specific applications is discussed in details. Three groups of RPBC were fabricated: i. polymeric micelles; ii. mixed polymeric micelles; iii. hybrid polymer-inorganic particles. All fabricated RPBCs contain polymeric component in their structure. The dissertation investigates how the changes of the responsive polymeric component properties are reflected in morphologies of RPBC.
520 $a The first group of RPBC, polymeric micelles, was formed by the self-assembly of amphiphilic invertible polymers (AIPs) synthesized in our group. AIPs self-assemble into invertible micellar assemblies (IMAs) in solvents of different polarity. In this work, IMAs ability to invert the structure as a response to the change in solvent polarity was demonstrated using 1H NMR spectroscopy and SANS. It was shown that the IMAs incorporate hydrophobic cargo either in the core or in the shell, depending on the chemical structure of cargo molecules. Following in vitro study demonstrates that loaded with drug (curcumin) IMAs are cytotoxic to osteosarcoma cells.
520 $a Mixed polymeric micelles represent another, more complex, RPBC morphologies studied in the dissertation. Mixed micelles were fabricated from AIPs and amphiphilic oligomers synthesized from pyromellitic dianhydride, polyethylene glycol methyl ethers, and alkanols/cholesterol. The combination of selected AIP and oligomers based on cholesterol results in mixed micelles with an increased drug-loading capacity (from 10% w/w loaded curcumin in single component IMAs to 26%w/w in mixed micelles).
520 $a Even more complex colloids are hybrid polymer-inorganic particles, the third RPBC group studied in dissertation. Material was designed as core--shell particles with superparamagnetic core engulfed by grafted polymer brushes. These particles were loaded with enzymes (cellulases), thus, are turned into enzymogels for cellulose bioconversion. The study demonstrates that such RPBCs can be used multiple times during hydrolysis and provide an about four-fold increase in glucose production in comparison to free enzymes.
590 $a School code: 0157.
650 4 $a Chemistry, Polymer. $3 1018428
650 4 $a Engineering, Biomedical. $3 1017684
650 4 $a Engineering, Materials Science. $3 1017759
650 4 $a Nanotechnology. $3 526235
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710 2 $a North Dakota State University. $b Coatings and Polymeric Materials. $3 2099338
773 0 $t Dissertation Abstracts International $g 75-12B(E).
790 $a 0157
791 $a Ph.D.
792 $a 2014
793 $a English
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