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The effects of NMDA receptor antagon...

Morales, Melissa.

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The effects of NMDA receptor antagonists on social interactions in adolescent and adult male Sprague-Dawley rats are subunit-dependent.

Record Type:	Electronic resources : Monograph/item
Title/Author:	The effects of NMDA receptor antagonists on social interactions in adolescent and adult male Sprague-Dawley rats are subunit-dependent./
Author:	Morales, Melissa.
Description:	180 p.
Notes:	Source: Dissertation Abstracts International, Volume: 75-01(E), Section: B.
Contained By:	Dissertation Abstracts International75-01B(E).
Subject:	Psychology, Psychobiology. -
Online resource:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=3597042
ISBN:	9781303445125

The effects of NMDA receptor antagonists on social interactions in adolescent and adult male Sprague-Dawley rats are subunit-dependent.
Morales, Melissa.

The effects of NMDA receptor antagonists on social interactions in adolescent and adult male Sprague-Dawley rats are subunit-dependent. - 180 p.

Source: Dissertation Abstracts International, Volume: 75-01(E), Section: B.

Thesis (Ph.D.)--State University of New York at Binghamton, 2013.

Adolescence is a developmental period characterized by both increases in ethanol consumption as well as increases in peer-directed social interactions, with adolescents typically reporting that they frequently consume alcohol for its socially facilitating properties. Animal models of adolescence have been developed and can be used to examine mechanisms contributing to these age-specific behaviors. Of particular interest is the NMDA subtype of the glutamate receptor, which has been shown to be involved in both ethanol- and social-related behaviors, with NMDA antagonists often mimicking the effects of ethanol on social and other behaviors. Chapter 1 examined the potential for three NMDA receptor antagonists: the non-competitive antagonist, MK-801, the NR2A antagonist, PEAQX, and the NR2B antagonist, ifenprodil, to induce social suppression in adolescent and adult rats. Adolescents required higher doses of MK-801 and ifenprodil to significantly reduce social interactions relative to adults, whereas adults demonstrated a relative insensitivity to PEAQX when compared with adolescents. Given that low doses of ethanol induce age-specific increases in social interactions in adolescent rodents, Chapter 2 investigated whether challenge with low doses of the NMDA antagonists MK-801, PEAQX, and ifenprodil similarly induced socially facilitating effects in adolescents. While all compounds tended to enhance overall social activity, ifenprodil also increased play and contact behaviors. Chapter 3 explored potential age differences in the ability of the partial glycine agonist, D-cycloserine for attenuating anxiety induced by ethanol or MK-801. D-cycloserine was unable to block ethanol- or MK-801- induced anxiety in the social interaction test in either adolescents or adults. The Western blot data revealed that acute ethanol decreased protein expression of the NR2A subunit in the amygdala, nucleus accumbens, and prefrontal cortex relative to saline-treated controls whereas a significant decrease in NR2B expression was only observed in the nucleus accumbens. Age differences only emerged for NR2A expression, with adolescents having significantly lower NR2A expression compared to adults. The current series of experiments show that the NMDA receptors, particularly the NR2B subunit, have a similar ontogenetic response on social activity as ethanol, making it an ideal target for exploring contributing factors for the elevated ethanol consumption levels seen during adolescence.

ISBN: 9781303445125Subjects--Topical Terms:

1017821
Psychology, Psychobiology.

The effects of NMDA receptor antagonists on social interactions in adolescent and adult male Sprague-Dawley rats are subunit-dependent.
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520 $a Adolescence is a developmental period characterized by both increases in ethanol consumption as well as increases in peer-directed social interactions, with adolescents typically reporting that they frequently consume alcohol for its socially facilitating properties. Animal models of adolescence have been developed and can be used to examine mechanisms contributing to these age-specific behaviors. Of particular interest is the NMDA subtype of the glutamate receptor, which has been shown to be involved in both ethanol- and social-related behaviors, with NMDA antagonists often mimicking the effects of ethanol on social and other behaviors. Chapter 1 examined the potential for three NMDA receptor antagonists: the non-competitive antagonist, MK-801, the NR2A antagonist, PEAQX, and the NR2B antagonist, ifenprodil, to induce social suppression in adolescent and adult rats. Adolescents required higher doses of MK-801 and ifenprodil to significantly reduce social interactions relative to adults, whereas adults demonstrated a relative insensitivity to PEAQX when compared with adolescents. Given that low doses of ethanol induce age-specific increases in social interactions in adolescent rodents, Chapter 2 investigated whether challenge with low doses of the NMDA antagonists MK-801, PEAQX, and ifenprodil similarly induced socially facilitating effects in adolescents. While all compounds tended to enhance overall social activity, ifenprodil also increased play and contact behaviors. Chapter 3 explored potential age differences in the ability of the partial glycine agonist, D-cycloserine for attenuating anxiety induced by ethanol or MK-801. D-cycloserine was unable to block ethanol- or MK-801- induced anxiety in the social interaction test in either adolescents or adults. The Western blot data revealed that acute ethanol decreased protein expression of the NR2A subunit in the amygdala, nucleus accumbens, and prefrontal cortex relative to saline-treated controls whereas a significant decrease in NR2B expression was only observed in the nucleus accumbens. Age differences only emerged for NR2A expression, with adolescents having significantly lower NR2A expression compared to adults. The current series of experiments show that the NMDA receptors, particularly the NR2B subunit, have a similar ontogenetic response on social activity as ethanol, making it an ideal target for exploring contributing factors for the elevated ethanol consumption levels seen during adolescence.
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