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Nanomaterials For Liquid Chromatogra...

Lu, Tian.

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Nanomaterials For Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry.

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	Nanomaterials For Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry./
作者:	Lu, Tian.
出版者:	Ann Arbor : ProQuest Dissertations & Theses, : 2013,
面頁冊數:	297 p.
附註:	Source: Dissertation Abstracts International, Volume: 77-07(E), Section: B.
Contained By:	Dissertation Abstracts International77-07B(E).
標題:	Analytical chemistry. -
電子資源:	http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10026230
ISBN:	9781339523132

Nanomaterials For Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry.
Lu, Tian.

Nanomaterials For Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry. - Ann Arbor : ProQuest Dissertations & Theses, 2013 - 297 p.

Source: Dissertation Abstracts International, Volume: 77-07(E), Section: B.

Thesis (Ph.D.)--The Ohio State University, 2013.

Techniques in analytical chemistry have been greatly improved by the application of developing nanotechnology. Separation science and mass spectrometry are two of the most widely-used techniques in industry. The enhanced performance of liquid chromatography (LC), solid phase extraction (SPE), laser desorption/ionization mass spectrometry was achieved here by using novel nanotechnology and nanomaterials.

ISBN: 9781339523132Subjects--Topical Terms:

3168300
Analytical chemistry.

Nanomaterials For Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry.
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245 1 0 $a Nanomaterials For Liquid Chromatography and Laser Desorption/Ionization Mass Spectrometry.
260 1 $a Ann Arbor : $b ProQuest Dissertations & Theses, $c 2013
300 $a 297 p.
500 $a Source: Dissertation Abstracts International, Volume: 77-07(E), Section: B.
500 $a Adviser: Susan V. Olesik.
502 $a Thesis (Ph.D.)--The Ohio State University, 2013.
520 $a Techniques in analytical chemistry have been greatly improved by the application of developing nanotechnology. Separation science and mass spectrometry are two of the most widely-used techniques in industry. The enhanced performance of liquid chromatography (LC), solid phase extraction (SPE), laser desorption/ionization mass spectrometry was achieved here by using novel nanotechnology and nanomaterials.
520 $a Electrospun polyvinyl alcohol (PVA) ultrathin layer chromatographic (UTLC) plates were fabricated using in-situ crosslinking electrospinning technique. The value of these ULTC plates was characterized using the separation of fluorescein isothiocyanate (FITC) labeled amino acids and the separation of amino acids followed visualization using ninhydrin. The selectivity of FITC labeled amino acids on PVA plate was compared with that on found using commercial silica high performance thin layer chromatographic plate. The efficiency of the separation varied with analyte concentration, size of capillary applicator, analyte solution volume, and mat thickness. The efficiency on PVA plate was greatly improved compared to the efficiency on the silica HPTLC plate. The hydrolysis products of aspartame in diet coke, aspartic acid and phenylalanine, were also successfully analyzed using PVA-UTLC plate.
520 $a Carbon has been used widely in HPLC due to its unique selectivity and high stability. Currently commercially-available carbon stationary phases are amorphous carbon. Amorphous carbon as a stationary phase has at least two sites of interaction with analytes: basal-plane and edge-plane carbon sites. The polarity and adsorption property of the two sites are different. However, the composition of the two sites cannot be controlled and predicted. Moreover, there may be different functional groups attached on edge-plane sites. In this work, homogenous carbon stationary phase is prepared by surface-directed liquid crystal assembly. By controlling the polarity of the substrates homogenous edge-plane or basal-plane carbon can be synthesized. To evaluate the performance of homogeneous carbon stationary phase, linear solvation energy relationships were used to compare these ordered carbon surfaces to commercially-available carbon stationary phases, including Hypercarb. Reversed-phase separations of nucleosides and nucleotides, and amino acids were demonstrated using the ordered carbon surfaces.
520 $a Homogeneous basal-plane carbon nanorods were also prepared for SPE. The homogenous basal-plane carbon nanorods were prepared with silver coated anodic aluminum oxide membrane template method. Benzene, ethylbenzene, phenol and p-cresol were used as analytes. The preliminary SPE results showed that the basal-plane carbon has higher extraction efficiency to the hydrophobic analytes, benzene and ethylbenzene and lower extraction efficiency to the polar analytes, phenol and p-cresol. The results further demonstrate that the basal-plane carbon surface is more hydrophobic and enhanced selectivity can be achieved by using homogenous carbon with different carbon alignment.
520 $a Electrospun polymer nanofibers (polyacrylonitrile, polyvinyl alcohol, and SU-8 photoresist), and carbon nanofibers pyrolyzed to final temperatures of 600, 800 and 900°C were used as substrates for surface-assisted laser desorption/ionization (SALDI) and matrix-enhanced surface-assisted laser desorption/ionization (ME-SALDI) analyses. Signals from polyethylene glycol with carbon nanofibrous substrates are greatly improved compared to those obtained with commercially-available stainless steel plates without organic matrix. Minimum fragmentation was observed using these substrates. Polyethylene glycol with a molecular weight as high as 900,000 Da was successfully detected using the carbon nanofibrous substrate processed to 800°C, which is the highest molecular weight that has been studied by SALDI. Small molecules were detected using carbon nanofibrous substrate processed to 800°C. High quality polystyrene mass spectra were obtained for the first time using SALDI nanofibrous polyacrylonitrile substrates. The results from ME-SALDI showed enhanced signal to noise ratios for the analytes with the electrospun nanofibrous substrates compared to using a conventional stainless steel substrate. A detection limit of 400 amol was achieved for angiotensin I using the carbon nanofibrous ME-SALDI substrate.
520 $a In addition, the modified carbon particles with photoluminescence were prepared. A fluorophore was attached to the carbon surface using aminosilane reagent. Because carbon is a strong fluorescent quencher, a spacer containing a long carbon chain was used to minimize the quenching from carbon.
590 $a School code: 0168.
650 4 $a Analytical chemistry. $3 3168300
650 4 $a Physical chemistry. $3 1981412
690 $a 0486
690 $a 0494
710 2 $a The Ohio State University. $b Chemistry. $3 1675507
773 0 $t Dissertation Abstracts International $g 77-07B(E).
790 $a 0168
791 $a Ph.D.
792 $a 2013
793 $a English
856 4 0 $u http://pqdd.sinica.edu.tw/twdaoapp/servlet/advanced?query=10026230