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The functional nucleus

Bazett-Jones, David P.

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The functional nucleus

Record Type:	Electronic resources : Monograph/item
Title/Author:	The functional nucleus/ edited by David P. Bazett-Jones, Graham Dellaire.
other author:	Bazett-Jones, David P.
Published:	Cham :Springer International Publishing : : 2016.,
Description:	vi, 513 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Cell nuclei. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-38882-3
ISBN:	9783319388823

The functional nucleus
The functional nucleus[electronic resource] /edited by David P. Bazett-Jones, Graham Dellaire. - Cham :Springer International Publishing :2016. - vi, 513 p. :ill., digital ;24 cm.

This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.

ISBN: 9783319388823

Standard No.: 10.1007/978-3-319-38882-3doiSubjects--Topical Terms:

595463
Cell nuclei.

LC Class. No.: QH595

Dewey Class. No.: 571.66

The functional nucleus
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020 $a 9783319388809 $q (paper)
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245 0 4 $a The functional nucleus $h [electronic resource] / $c edited by David P. Bazett-Jones, Graham Dellaire.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2016.
300 $a vi, 513 p. : $b ill., digital ; $c 24 cm.
520 $a This book gives an in-depth overview on nuclear structure and function. It clearly shows that the epigenome and the three-dimensional organization of the nucleus are not independent properties. The intimate relationship between the location and the epigenetic modifications of gene loci is highlighted. Finally, it shows that the complex three-dimensional organization of the nucleus is not just of academic interest: The structure, composition and function of virtually all of the sub-nuclear compartments identified so far can be implicated to a list of human genetic diseases. Hence, a detailed elucidation of how these domains are assembled and function will provide new opportunities for therapeutic intervention in clinical practice.
650 0 $a Cell nuclei. $3 595463
650 1 4 $a Life Sciences. $3 890838
650 2 4 $a Nucleic Acid Chemistry. $3 1243992
650 2 4 $a Cell Biology. $3 892383
650 2 4 $a Cytogenetics. $3 664496
700 1 $a Bazett-Jones, David P. $3 3166259
700 1 $a Dellaire, Graham. $3 3166260
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-38882-3
950 $a Biomedical and Life Sciences (Springer-11642)