Biobetters = protein engineering to ...
Rosenberg, Amy.

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  • Biobetters = protein engineering to approach the curative /
  • 紀錄類型: 書目-電子資源 : Monograph/item
    正題名/作者: Biobetters/ edited by Amy Rosenberg, Barthelemy Demeule.
    其他題名: protein engineering to approach the curative /
    其他作者: Rosenberg, Amy.
    出版者: New York, NY :Springer New York : : 2015.,
    面頁冊數: xv, 378 p. :ill., digital ;24 cm.
    內容註: Introduction -- Targeting glucocerebrosidase to macrophages for effective treatment of patients with Gaucher disease: setting the paradigm of a "fit for purpose" approach to enzyme replacement therapy -- Challenges of Enzyme Replacement Therapy: Poor tissue distribution in lysosomal diseases using Pompe disease as a model -- Muscle targeting -- Blood-Brain Barrier Targeting of Therapeutic Lysosomal Enzymes -- Novel Methods for Addressing Immunogenicity in Therapeutic Enzymes -- Structure of monoclonal antibodies -- Prediction of aggregation in vivo by studies of therapeutic proteins in human plasma -- Effect of Hydrolytic Degradation on the In Vivo Properties of Monoclonal Antibodies -- Oxidation of proteins in the in-vivo environment: what we know; what we need to study and potential mitigation strategies -- Molecular assessment: balancing affinity, PK and manufacturability -- Perspectives on engineering biobetter therapeutic proteins with greater stability in inflammatory environments -- Antibody-like molecules designed for superior targeting and pharmacokinetics -- Alternative protein scaffolds as novel biotherapeutics -- Current strategies for pharmacokinetic optimization -- Biosimilar and Biobetter Scenarios for the US and Europe: What Should We Expect? -- Regulatory considerations for approval of biobetter products.
    Contained By: Springer eBooks
    標題: Protein engineering. -
    電子資源: http://dx.doi.org/10.1007/978-1-4939-2543-8
    ISBN: 9781493925438
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W9274095 電子資源 11.線上閱覽_V 電子書 EB TP248.65.P76 一般使用(Normal) 在架 0
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