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Asymmetric synthesis of bioactive la...

Doran, Robert.

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Asymmetric synthesis of bioactive lactones and the development of a catalytic asymmetric synthesis of alpha-Aryl ketones

Record Type:	Language materials, printed : Monograph/item
Title/Author:	Asymmetric synthesis of bioactive lactones and the development of a catalytic asymmetric synthesis of alpha-Aryl ketones/ by Robert Doran.
Author:	Doran, Robert.
Published:	Cham :Springer International Publishing : : 2015.,
Description:	xxi, 202 p. :ill., digital ;24 cm.
Contained By:	Springer eBooks
Subject:	Asymmetric synthesis. -
Online resource:	http://dx.doi.org/10.1007/978-3-319-20544-1
ISBN:	9783319205441 (electronic bk.)

Asymmetric synthesis of bioactive lactones and the development of a catalytic asymmetric synthesis of alpha-Aryl ketones
Doran, Robert.

Asymmetric synthesis of bioactive lactones and the development of a catalytic asymmetric synthesis of alpha-Aryl ketones[electronic resource] /by Robert Doran. - Cham :Springer International Publishing :2015. - xxi, 202 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereocontrol, which is significant because it allows the configuration of a new stereocentre to be controlled by a simple change of proton source.

ISBN: 9783319205441 (electronic bk.)

Standard No.: 10.1007/978-3-319-20544-1doiSubjects--Topical Terms:

604596
Asymmetric synthesis.

LC Class. No.: QD262

Dewey Class. No.: 547.2

Asymmetric synthesis of bioactive lactones and the development of a catalytic asymmetric synthesis of alpha-Aryl ketones
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020 $a 9783319205434 (paper)
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100 1 $a Doran, Robert. $3 2156345
245 1 0 $a Asymmetric synthesis of bioactive lactones and the development of a catalytic asymmetric synthesis of alpha-Aryl ketones $h [electronic resource] / $c by Robert Doran.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2015.
300 $a xxi, 202 p. : $b ill., digital ; $c 24 cm.
490 1 $a Springer theses, $x 2190-5053
520 $a This thesis addresses two fundamental areas in contemporary organic chemistry: synthesis of natural products and catalytic asymmetric synthesis. Firstly, a new methodology, developed by our research group, which allows the asymmetric synthesis of lactones, a structural unit ubiquitous in natural products, was utilised in the synthesis of a number of natural product analogues that showed significant biological activity. Secondly, the development of a catalytic asymmetric synthesis of a key structural motif present in a number of natural products and pharmaceuticals was accomplished. During the course of this work we discovered dual stereocontrol, which is significant because it allows the configuration of a new stereocentre to be controlled by a simple change of proton source.
650 0 $a Asymmetric synthesis. $3 604596
650 0 $a Biosynthesis. $3 516407
650 0 $a Ketones. $3 1619241
650 1 4 $a Chemistry. $3 516420
650 2 4 $a Organic Chemistry. $3 890856
650 2 4 $a Catalysis. $3 560465
650 2 4 $a Medicinal Chemistry. $3 892420
710 2 $a SpringerLink (Online service) $3 836513
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830 0 $a Springer theses. $3 1314442
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-20544-1
950 $a Chemistry and Materials Science (Springer-11644)