東華大學圖書館 |

語系: 繁體中文

說明(常見問題)

回圖書館首頁

手機版館藏查詢

登入

回首頁

切換: 標籤 | MARC模式 | ISBD

High-resolution profiling of protein...

Munschauer, Mathias.

FindBook

Google Book

Amazon

博客來

High-resolution profiling of protein-RNA interactions

紀錄類型:	書目-電子資源 : Monograph/item
正題名/作者:	High-resolution profiling of protein-RNA interactions/ by Mathias Munschauer.
作者:	Munschauer, Mathias.
出版者:	Cham :Springer International Publishing : : 2015.,
面頁冊數:	xxiii, 121 p. :ill., digital ;24 cm.
內容註:	Introduction -- Mapping Regulatory Interactions of the Rna-Binding Protein Lin28b -- Exploring The Sequence Space Contacted by the Ensemble of Rna-Binding Proteins -- Revealing Cell-Type Specific Differences in Protein Occupancy on Rna -- Discussion.
Contained By:	Springer eBooks
標題:	RNA-protein interactions. -
電子資源:	http://dx.doi.org/10.1007/978-3-319-16253-9
ISBN:	9783319162539 (electronic bk.)

High-resolution profiling of protein-RNA interactions
Munschauer, Mathias.

High-resolution profiling of protein-RNA interactions[electronic resource] /by Mathias Munschauer. - Cham :Springer International Publishing :2015. - xxiii, 121 p. :ill., digital ;24 cm. - Springer theses,2190-5053. - Springer theses..

Introduction -- Mapping Regulatory Interactions of the Rna-Binding Protein Lin28b -- Exploring The Sequence Space Contacted by the Ensemble of Rna-Binding Proteins -- Revealing Cell-Type Specific Differences in Protein Occupancy on Rna -- Discussion.

The work reported in this book represents an excellent example of how creative experimentation and technology development, complemented by computational data analysis, can yield important insights that further our understanding of biological entities from a systems perspective. The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel 'protein occupancy profiling' technology that for the first time captured the mRNA sequence space contacted by the ensemble of expressed RNA binders. Application of protein occupancy profiling to eukaryotic cells revealed that extensive sequence stretches in 3' UTRs can be contacted by RBPs and that evolutionary conservation as well as negative selection act on protein-RNA contact sites, suggesting functional importance. Comparative analysis of the RBP-bound sequence space has the potential to unravel putative cis-acting RNA elements without a priori knowledge of the bound regulators. Here, Dr. Munschauer provides a comprehensive introduction to the field of post-transcriptional gene regulation, examines state-of-the-art technologies, and combines the conclusions from several journal articles into a coherent and logical story from the frontiers of systems-biology inspired life science. This thesis, submitted to the Department of Biology, Chemistry and Pharmacy at Freie Universitat Berlin, was selected as outstanding work by the Berlin Institute for Medical Systems Biology at the Max-Delbrueck Center for Molecular Medicine, Germany.

ISBN: 9783319162539 (electronic bk.)

Standard No.: 10.1007/978-3-319-16253-9doiSubjects--Topical Terms:

569547
RNA-protein interactions.

LC Class. No.: QP623.8.P75

Dewey Class. No.: 572.88

High-resolution profiling of protein-RNA interactions
LDR:02779nmm a2200325 a 4500 001 1997965
003 DE-He213
005 20151027133428.0
006 m d
007 cr nn 008maaau
008 151112s2015 gw s 0 eng d
020 $a 9783319162539 (electronic bk.)
020 $a 9783319162522 (paper)
024 7 $a 10.1007/978-3-319-16253-9 $2 doi
035 $a 978-3-319-16253-9
040 $a GP $c GP
041 0 $a eng
050 4 $a QP623.8.P75
072 7 $a MQW $2 bicssc
072 7 $a TEC009000 $2 bisacsh
082 0 4 $a 572.88 $2 23
090 $a QP623.8.P75 $b M969 2015
100 1 $a Munschauer, Mathias. $3 2139408
245 1 0 $a High-resolution profiling of protein-RNA interactions $h [electronic resource] / $c by Mathias Munschauer.
260 $a Cham : $b Springer International Publishing : $b Imprint: Springer, $c 2015.
300 $a xxiii, 121 p. : $b ill., digital ; $c 24 cm.
490 1 $a Springer theses, $x 2190-5053
505 0 $a Introduction -- Mapping Regulatory Interactions of the Rna-Binding Protein Lin28b -- Exploring The Sequence Space Contacted by the Ensemble of Rna-Binding Proteins -- Revealing Cell-Type Specific Differences in Protein Occupancy on Rna -- Discussion.
520 $a The work reported in this book represents an excellent example of how creative experimentation and technology development, complemented by computational data analysis, can yield important insights that further our understanding of biological entities from a systems perspective. The book describes how the study of a single RNA-binding protein and its interaction sites led to the development of the novel 'protein occupancy profiling' technology that for the first time captured the mRNA sequence space contacted by the ensemble of expressed RNA binders. Application of protein occupancy profiling to eukaryotic cells revealed that extensive sequence stretches in 3' UTRs can be contacted by RBPs and that evolutionary conservation as well as negative selection act on protein-RNA contact sites, suggesting functional importance. Comparative analysis of the RBP-bound sequence space has the potential to unravel putative cis-acting RNA elements without a priori knowledge of the bound regulators. Here, Dr. Munschauer provides a comprehensive introduction to the field of post-transcriptional gene regulation, examines state-of-the-art technologies, and combines the conclusions from several journal articles into a coherent and logical story from the frontiers of systems-biology inspired life science. This thesis, submitted to the Department of Biology, Chemistry and Pharmacy at Freie Universitat Berlin, was selected as outstanding work by the Berlin Institute for Medical Systems Biology at the Max-Delbrueck Center for Molecular Medicine, Germany.
650 0 $a RNA-protein interactions. $3 569547
650 0 $a RNA polymerases. $3 669190
650 1 4 $a Engineering. $3 586835
650 2 4 $a Biomedical Engineering. $3 720279
650 2 4 $a Systems Biology. $3 928020
650 2 4 $a Computational Biology/Bioinformatics. $3 898313
710 2 $a SpringerLink (Online service) $3 836513
773 0 $t Springer eBooks
830 0 $a Springer theses. $3 1314442
856 4 0 $u http://dx.doi.org/10.1007/978-3-319-16253-9
950 $a Engineering (Springer-11647)