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Bioinformatics of non small cell lun...

Kashyap, Amita.

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Bioinformatics of non small cell lung cancer and the ras proto-oncogene

Record Type:	Electronic resources : Monograph/item
Title/Author:	Bioinformatics of non small cell lung cancer and the ras proto-oncogene/ by Amita Kashyap, D. Bujamma, Naresh Babu M.
Author:	Kashyap, Amita.
other author:	Bujamma, D.
Published:	Singapore :Springer Singapore : : 2015.,
Description:	vii, 72 p. :ill. (some col.), digital ;24 cm.
[NT 15003449]:	Introduction -- Review of Literature -- Materials and Methods (Tools and Databases) -- Flowchart -- Conclusion.-References.
Contained By:	Springer eBooks
Subject:	Bioinorganic chemistry. -
Online resource:	http://dx.doi.org/10.1007/978-981-4585-08-8
ISBN:	9789814585088 (electronic bk.)

Bioinformatics of non small cell lung cancer and the ras proto-oncogene
Kashyap, Amita.

Bioinformatics of non small cell lung cancer and the ras proto-oncogene[electronic resource] /by Amita Kashyap, D. Bujamma, Naresh Babu M. - Singapore :Springer Singapore :2015. - vii, 72 p. :ill. (some col.), digital ;24 cm. - Springer briefs in applied sciences and technology. Forensic and medical bioinformatics,2191-530X. - SpringerBriefs in applied sciences and technology.Forensic and medical bioinformatics..

Introduction -- Review of Literature -- Materials and Methods (Tools and Databases) -- Flowchart -- Conclusion.-References.

Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10-30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.

ISBN: 9789814585088 (electronic bk.)

Standard No.: 10.1007/978-981-4585-08-8doiSubjects--Topical Terms:

599790
Bioinorganic chemistry.

LC Class. No.: QP531

Dewey Class. No.: 572.51

Bioinformatics of non small cell lung cancer and the ras proto-oncogene
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505 0 $a Introduction -- Review of Literature -- Materials and Methods (Tools and Databases) -- Flowchart -- Conclusion.-References.
520 $a Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10-30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.
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