| 內容註: |
1. Introducing pharmacokinetic and pharmacodynamic concepts / Malcolm Rowland -- 2. In vitro enzyme kinetics applied to drug-metabolizing enzymes / Kenneth R. Korzekwa -- 3. Human cytochromes P450 and their role in metabolism-based drug-drug interactions / Stephen E. Clarke and Barry C. Jones -- 4. UDP-glucuronosyltransferases / Rory P. Remmel, Jin Zhou, and Upendra A. Argikar -- 5. Drug-drug interactions involving the membrane transport process / Hiroyuki Kusuhara and Yuichi Sugiyama -- 6. In vitro models for studying induction of cytochrome P450 enzymes / Jose M. Silva and Deborah A. Nicoll-Griffith -- 7. In vitro approaches for studying the inhibition of drug-metabolizing enzymes and identifying the drug-metabolizing enzymes responsible for the metabolism of drugs (reaction phenotyping) with emphasis on cytochrome P450 / Brian W. Ogilvie ... [et al.] -- 8. The role of P-glycoprotein in drug disposition : significance to drug development / Matthew D. Troutman ... [et al.] -- 9. Cytochrome P450 protein modeling and ligand docking / K. Anton Feenstra, Chris de Graaf, and Nico P.E. Vermeulen -- 10. Role of the gut mucosa in metabolically based drug-drug interactions / Kenneth E. Thummel, Danny D. Shen, and Nina Isoherannen -- 11. Mechanism-based inhibition of human cytochromes P450 : in vitro kinetics and in vitro-in vivo correlations / Xin Zhang, David R. Jones, and Stephen D. Hall -- 12. Transporter-mediated drug interactions : molecular mechanisms and clinical implications / Jiunn H. Lin -- 13. Metabolism and transport drug interaction database : a web-based research and analysis tool / Houda Hachad, Isabelle Ragueneau-Majlessi, and Ren�e H. Levy -- 14. In vivo probes for studying induction and inhibition of cytochrome P450 enzymes in humans / Grant R. Wilkinson -- 15. Drug-drug interactions : clinical perspective / David J. Greenblatt and Lisa L. von Moltke -- 16. An integrated approach to assessing drug-drug interactions : a regulatory perspective / Shiew-Mei Huang, Lawrence J. Lesko, and Robert Temple -- 17. Drug-drug interactions : toxicological perspectives / Sidney D. Nelson -- 18. Drug-drug interactions : marketing perspectives / Kevin J. Petty and Jose M. Vega. |